Sökning: "bacterial effectors"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden bacterial effectors.

  1. 1. Synthesis and investigation of bacterial effector molecules

    Författare :Michael Franz Albers; Christian Hedberg; Christian Hackenberger; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacterial effectors; organic synthesis; Legionella; PTM; peptide synthesis; nucleotide chemistry; Biorganic Chemistry; bioorganisk kemi;

    Sammanfattning : During infections, bacterial microorganisms initiate profound interactions with mammalian host cells. Usually defense mechanisms of the host destroy intruding bacteria in rapid manner. However, many bacterial pathogens have evolved in a way to avoid these mechanisms. LÄS MER

  3. 2. Tissue responses and host transcriptomics in bacterial infections

    Författare :Jorrit Boekel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bacterial infections can damage host tissue and are as such a potential threat to their hosts. To protect themselves from pathogens, hosts therefore can employ diverse immune reactions. LÄS MER

  4. 3. It Takes Two to Tango : Bacterial heterogeneity and host cell features govern Salmonella infection

    Författare :Viktor Ek; Mikael E. Sellin; Francisco García del Portillo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Salmonella; swimming; swim pattern; targetting; virulence; invasion; host-pathogen interactions; epithelium; epithelial cells; macrophages; monocytes; monolayer; flagella; genome; genetic; barcoding; discreet-invasion; shape; morphology; antibiotics; persistence; Mikrobiologi; Microbiology;

    Sammanfattning : Salmonella enterica serovar Typhimurium (S.Tm) causes enterocolitis with significant worldwide morbidity and mortality. The general aim of this thesis is to investigate variation in host cell invasion mechanisms used by S.Tm across different host cell contexts, as well as the influence of bacterial cell-cell heterogeneity on invasion-relevant S. LÄS MER

  5. 4. Interactions between innate immune effectors and multidrug resistant bacteria

    Författare :Harpa Káradóttir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antibiotic resistance is an increasingly difficult problem in the clinic, where conventional antibiotics are failing, and new alternative solutions are in high demand. Infections caused by Gram-negative bacteria with multi drug resistance (MDR) mechanisms are increasing globally, and treatment options are limited. LÄS MER

  7. 5. Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy

    Författare :Jonathan Sjögren; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; endoglycosidase; Streptococcus pyogenes; glycosylation; EndoS;

    Sammanfattning : A majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. LÄS MER