Sökning: "single-cell analysis"

Visar resultat 11 - 15 av 216 avhandlingar innehållade orden single-cell analysis.

1. 11. Imaging-based methods for NK cell studies at the single-cell level

   Författare :Quentin Verron; Björn Önfelt; Niklas Sandström; Michael Dustin; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; NK cells; microscopy; single-cell; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

   Sammanfattning : The immune system provides defense against infectious agents such as viruses, bacteria and parasites. Besides eliminating extracellular agents, the immune system also constantly monitors our own cells for signs of transformation, including tumor development and virus infection. LÄS MER

3. 12. Single cell analysis of checkpoints in G1

   Författare :Hanna-Stina Martinsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cell cycle; restriction point; cyclin D; pRb; rRNA synthesis; cell growth; attachment;

   Sammanfattning : It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular growth factors, is often aberrant in cancer cells. LÄS MER

4. 13. Variational methods for phylogeny and single-cell genomics

   Författare :Hazal Koptagel; Jens Lagergren; Alexandre Bouchard-Côté; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Variational inference; single-cell DNA sequencing; cell lineage tree; Bayesian phylogenetic tree inference; Variationsinferens; encellig DNA-sekvensering; cellhärkomstträd; Bayesiansk fylogenetisk trädinferens; Varyasyonel çıkarım; tek hücre DNA dizilimi; hücre soy ağacı; Bayesçi filogenetik ağaç çıkarımı; Datalogi; Computer Science;

   Sammanfattning : The investigation of the evolutionary history of organisms, both at the cellular level and at the species level, is a relevant research topic in computational biology. These investigations lead to a deeper understanding of developmental history, cancer progression, the genetic similarity of species, and more. LÄS MER

5. 14. Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems

   Författare :Parashar Dhapola; Avdelningen för molekylär hematologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cell; Single-Cell; Genomics; Epigenomics; transcriptomics; bioinformatics;

   Sammanfattning : The focus of this doctoral dissertation was to develop novel and scalable computational genomics methods for analysing single-cell genomic modalities. Scarf, a highly memory-efficient single-cell data analysis toolkit, was developed to enable an analysis of very large-scale datasets on personal computers, and the execution of parallel workflows on server-scale computational systems. LÄS MER

7. 15. Illumination in single cell optical microscopy studies - friend and foe

   Författare :Kristofer Bodvard; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; yeast; transcription factors; signalling; fluorescence microscopy; Saccharomyces cerevisiae; light-induced stress; phototoxicity; single cell imaging;

   Sammanfattning : This thesis focuses on how to use light as a biological stress factor in optical microscopy experiments and simultaneously use the illumination to image the spatial and temporal protein dynamics in single yeast cells. The stress responses to environmental changes other than light have been extensively investigated in budding yeast, Saccharomyces cerevisiae, often using techniques based on population averages. LÄS MER