Sökning: "rRNA synthesis"
Visar resultat 1 - 5 av 37 avhandlingar innehållade orden rRNA synthesis.
1. Exotic Ribosomal Enzymology
Sammanfattning : This thesis clarifies intriguing enzymology of the ribosome, the multiRNA/multiprotein complex that catalyzes protein synthesis (translation). The large ribosomal RNAs (23S and 16S rRNAs in E. coli) are post-transcriptionally modified by many specific modification enzymes, yet the functions of the modifications remain enigmatic. LÄS MER
2. Molecular Interplay of Antibiotics on the Bacterial Ribosome
Sammanfattning : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. LÄS MER
3. High-resolution phenotypic profiling of a eukaryotic ribosome
Sammanfattning : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. LÄS MER
4. Removal and Replacement of Ribosomal Proteins : Effects on Bacterial Fitness and Ribosome Function
Sammanfattning : Protein synthesis is a complex process performed by sophisticated cellular particles known as ribosomes. Although RNA constitutes the major structural and functional component, ribosomes from all kingdoms contain an extensive array of proteins with largely undefined functional roles. LÄS MER
5. Genomics and metabolomics in the North Atlantic deep-sea sponge Geodia barretti
Sammanfattning : Sponges are among the earliest diverging taxa in the animal tree of life. They are sessile, filter-feeding animals found in marine and freshwater habitats. Many species are characterized by a close, specific and consistent association with microbes, mainly Bacteria and Archaea. LÄS MER