Sökning: "Epigenomics"
Hittade 5 avhandlingar innehållade ordet Epigenomics.
1. Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems
Sammanfattning : The focus of this doctoral dissertation was to develop novel and scalable computational genomics methods for analysing single-cell genomic modalities. Scarf, a highly memory-efficient single-cell data analysis toolkit, was developed to enable an analysis of very large-scale datasets on personal computers, and the execution of parallel workflows on server-scale computational systems. LÄS MER
2. Spatial transcriptome and epigenome analysis with focus on prostate cancer
Sammanfattning : Each cancer is unique, and therefore the use of general treatments are often suboptimal. If we can understand the mechanisms of cancer development, we might be able to develop effective treatments tailored to each patient. Our bodies are complex three-dimensional structures and how things are organized correlate with proper functioning. LÄS MER
3. Multiomics strategy in clinical immunology aiding unsolved antibody deficiencies
Sammanfattning : Clinical and immunological phenotyping of a cohort of consecutive dysgammaglobulinemic patients with unknown genetic defects underwent genomic (e.g. whole-exome sequencing) and other relative multiomics (e.g. LÄS MER
4. Comparative bioinformatics analyses of transcriptome and epigenome data using bovine model systems
Sammanfattning : Bioinformatics methodology is used to understand complex biological processes in molecular biology, genetics and epigenetics. This thesis performed analysis of the complex biological processes controlling reproduction in mammals including dairy cattle. LÄS MER
5. Deciphering the transcriptional regulation code in colorectal cancer genome
Sammanfattning : Colorectal cancer (CRC) is the third most common cancer type to threaten life for both men and women in the developed world. The molecular mechanism of CRC is very complicated and involves changes in different categories of biological processes, among which a large number of mutations affecting either coding sequence of transcription factors (TFs) or their binding sites in genome are included. LÄS MER