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1. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry
Sammanfattning : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. LÄS MER
2. Structural Reformulations in System Identification
Sammanfattning : In system identification, the choice of model structure is important and it is sometimes desirable to use a flexible model structure that is able to approximate a wide range of systems. One such model structure is the Wiener class of systems, that is, systems where the input enters a linear time-invariant subsystem followed by a time-invariant nonlinearity. LÄS MER
3. A Study in RNA Bioinformatics : Identification, Prediction and Analysis
Sammanfattning : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. LÄS MER
4. Initialization Methods for System Identification
Sammanfattning : In the system identification community a popular framework for the problem of estimating a parametrized model structure given a sequence of input and output pairs is given by the prediction-error method. This method tries to find the parameters which maximize the prediction capability of the corresponding model via the minimization of some chosen cost function that depends on the prediction error. LÄS MER
5. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development
Sammanfattning : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). LÄS MER