Sökning: "second-line drugs"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden second-line drugs.

  1. 1. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    Författare :Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. LÄS MER

  3. 2. Drug-resistant Mycobacterium tuberculosis in Estonia

    Författare :Annika Krüüner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tuberculosis; Estonia; M. tuberculosis; drug resistance; MDR-TB; Beijing genotype; cross-resistance; kanamycin; amikacin; rrs mutations; 16S rRNA; exposure; nosocomial transmission; mycobacterial persistence; re-infection; DST; second-line drugs; Bactec; 460; DNA fingerprinting; spoligotyping;

    Sammanfattning : Tuberculosis (TB) infection and disease patterns among different populations are extremely heterogeneous. This thesis explores mainly by microbiological methods the epidemiology of TB in Estonia. Through the work high rates of drug resistance were found. LÄS MER

  4. 3. Treatment of uncomplicated malaria in Guinea-Bissau

    Författare :Paul Erik Kofoed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chloroquine; sulphadoxine; pyrimethamine; amodiaquine; quinine; artemisinine; malaria; children; Guinea-Bissau; efficacy; effectiveness.;

    Sammanfattning : Treatment of malaria has become increasingly difficult due to high levels of resistance to the cheap and commonly used antimalarials. In Guinea-Bissau, the first line drug is chloroquine (CQ), the second line drug is sulfadoxine-pyrimethamine (S/P), and the third line therapy is quinine (QU). LÄS MER

  5. 4. Epidemiological studies on socioeconomic inequalities and cardiovascular disease : prevention, progression and prognosis

    Författare :Ninoa Malki; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease (CVD) accounts for 30% of global mortality and is the most common cause of death in the world. Population-wide prevention strategies as well as healthcare interventions have led to a decrease in CVD incidence and mortality. LÄS MER

  7. 5. Pharmacometrics to improve evaluation and individualization of anticancer drug treatment

    Författare :Sreenath Madathil Krishnan; Lena Friberg; Mats Karlsson; Zinnia Parra Gillén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacodynamics; survival modeling;

    Sammanfattning : The success rate in clinical development of newer anti-cancer molecules is the lowest compared to other major diseases. Improving the success rate and better early evaluation of efficacy of anti-cancer drugs remain challenging obstacles. LÄS MER