Sökning: "MDR-TB"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet MDR-TB.

  1. 1. Drug-resistant Mycobacterium tuberculosis in Estonia

    Författare :Annika Krüüner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tuberculosis; Estonia; M. tuberculosis; drug resistance; MDR-TB; Beijing genotype; cross-resistance; kanamycin; amikacin; rrs mutations; 16S rRNA; exposure; nosocomial transmission; mycobacterial persistence; re-infection; DST; second-line drugs; Bactec; 460; DNA fingerprinting; spoligotyping;

    Sammanfattning : Tuberculosis (TB) infection and disease patterns among different populations are extremely heterogeneous. This thesis explores mainly by microbiological methods the epidemiology of TB in Estonia. Through the work high rates of drug resistance were found. LÄS MER

  3. 2. Rapid tests for multidrug resistant tuberculosis in low income settings

    Författare :Freddie Bwanga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tuberculosis (TB) is at epidemic levels in the resource-limited settings (RLSs) due to HIV/AIDS, poverty and insufficient TB control programmes. These factors are also contributing to TB drug resistance. Patients with multidrug drug resistant tuberculosis (MDR-TB) do not respond to first line drugs. LÄS MER

  4. 3. Novel treatment strategies for multidrug-resistant tuberculosis

    Författare :Lina Davies Forsman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tuberculosis is the leading cause of death from a single infectious agent in the world, surpassing the annual death toll of both malaria and HIV combined. The rise in multidrug-resistant tuberculosis (MDR-TB) has further exacerbated the situation, as this form of TB is more difficult and time-consuming to treat, with dismal cure rates. LÄS MER

  5. 4. Treatment optimisation of multidrug-resistant tuberculosis

    Författare :Johanna Kuhlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A successful treatment outcome is seen in only 60% of persons treated for multidrugresistant tuberculosis (MDR-TB) worldwide, defined as resistance to both rifampicin and isoniazid. To improve these disturbingly low numbers, treatment optimisation is highly needed. LÄS MER

  7. 5. Rapid detection of drug resistance and genetic characterisation of Mycobacterium tuberculosis isolates in Honduras

    Författare :Senia Rosales; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: New challenges for tuberculosis (TB) control are emerging in the 21st century. The deadly combination TB/HIV as well as the development and spread of new forms of drug resistance are some examples. In this context, the timely detection of TB cases, especially of those with resistant TB is important. LÄS MER