Sökning: "receptor characterization"

Visar resultat 11 - 15 av 263 avhandlingar innehållade orden receptor characterization.

  1. 11. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization

    Författare :Cecilia Mattsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dopamine D2 receptor; serotonin reuptake transporter; monoamine oxidase; 5-HT6 receptor; DOPAC; 5-HIAA; 3-tetrahydropyridine indole; 3-piperidine indole; 3- pyrrolidin-1-ylmethyl chromen-2-one; dopamine D2 receptor;

    Sammanfattning : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. LÄS MER

  3. 12. Characterization of the cellular receptor for coxsackievirus and adenovirus

    Författare :Momina Mirza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : CAR, the cellular receptor for coxsackievirus and adenovirus, was discovered in 1997. CAR is an evolutionary conserved transmembrane protein that belongs to the CTX subfamily within the large immunoglobulin superfamily. At the intracellular tail, CAR has a PDZ domain binding motif suggesting that CAR is part of a larger protein complex. LÄS MER

  4. 13. Molecular basis of estrogen receptor antagonism

    Författare :Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

    Sammanfattning : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. LÄS MER

  5. 14. Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia

    Författare :Kristina Karrman; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leukmia; genetic characterization; pediatric;

    Sammanfattning : The aim of my thesis has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. LÄS MER

  7. 15. Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy

    Författare :Christian Seeger; U Helena Danielson; Sarah Lummis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surface plasmon resonance; biosensor; AMPA receptor; GABAA receptor; ligand-gated ion channel; A-kinase anchoring protein; caldendrin; calmodulin; HIV; fragment based drug discovery; Biokemi; Biochemistry; Neuroscience; Neurovetenskap;

    Sammanfattning : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. LÄS MER