Sökning: "pulmonary drug delivery"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden pulmonary drug delivery.

1. 1. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

   Författare :Ann Tronde; Gerrit Borchard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Sammanfattning : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. LÄS MER

3. 2. Drug absorption in the lungs : studies in the isolated perfused rat lung model combined with physiologically based biopharmaceutics modelling

   Författare :Johanna Eriksson; Hans Lennernäs; Erik Sjögren; Helena Thörn; Ben Forbes; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug absorption; physiologically based biopharmaceutics modeling; pulmonary drug delivery; Biofarmaci; Biopharmaceutics;

   Sammanfattning : Pulmonary delivery of drugs is the preferred route of administration for treatment of local lung diseases like asthma and chronic obstructive pulmonary disease. Recently, there has also been increased interest in systemic delivery of drugs via the lungs to avoid problems with low and/or variable gastrointestinal absorption, and as a needle-free alternative for drugs that cannot be ingested. LÄS MER

4. 3. Ceramic Materials as Drug Delivery Systems

   Författare :Amina Vazda; Håkan Engqvist; Santos Hélder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery; ceramics; Abuse deterrent; inhalation; single-crystals;

   Sammanfattning : The aim of this thesis is to evaluate ceramic materials for drug delivery drugs applications. Three delivery routes were investigated; abuse-deterrent oral formulation, inhalation, and novel ceramic crystals with drug entrapped. A geopolymer matrix was developed in order to withstand non-medical abuse such as crushing, snorting, extraction etc. LÄS MER

5. 4. Lipid-based liquid crystals as drug delivery vehicles for antimicrobial peptides

   Författare :Lukas Boge; Martin Andersson; Lovisa Ringstad; RISE; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Liquid crystals; liquid crystalline nanoparticles; cubosome; hexosome; phase behavior; antimicrobial peptide; AMP; glycerol monooleate; proteolysis; antimicrobial effect; antimicrobial resistance; bacterial membrane; membrane interaction; infection; topical delivery; pulmonary delivery;

   Sammanfattning : The development of antimicrobial resistance is a great challenge within health sectors worldwide. Thus, demand for new, efficient treatments is urgent in order to treat various bacterial infections. Antimicrobial peptides (AMPs) are a group of antibiotics that have gained more and more attraction in the past decade. LÄS MER

7. 5. Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems : With a focus on controlled release systems

   Författare :Irès van der Zwaan; Göran Frenning; Per Hansson; Rebecca Fransson; Alessandra Rossi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug delivery; in vitro dissolution; mechanistic model; controlled release; physiologically based biopharmaceutics modelling;

   Sammanfattning : Pulmonary drug delivery has been used for decades to treat local diseases like asthma. When using the pulmonary route to deliver drugs, several important lung features are being used, such as a large surface area available for absorption, high organ vascularization, and a thin blood-alveolar barrier. LÄS MER