Sökning: "physiologically based biopharmaceutics modeling"

Hittade 3 avhandlingar innehållade orden physiologically based biopharmaceutics modeling.

  1. 1. Physiologically based pharmacokinetic modeling in risk assessment - Development of Bayesian population methods

    Författare :Fredrik Jonsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; methyl chloride; dichloromethane; toluene; styrene; uncertainty; intra- individual variability; risk assessment; physiologically based modeling; Markov chain Monte Carlo; PBPK; Bayesian; population modeling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Sammanfattning : In risk assessment of risk chemicals, variability in susceptibility in the population is an important aspect. The health hazard of a pollutant is related to the internal exposure to the chemical, i.e. the target dose, rather than the external exposure. LÄS MER

  3. 2. Drug absorption in the lungs : studies in the isolated perfused rat lung model combined with physiologically based biopharmaceutics modelling

    Författare :Johanna Eriksson; Hans Lennernäs; Erik Sjögren; Helena Thörn; Ben Forbes; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug absorption; physiologically based biopharmaceutics modeling; pulmonary drug delivery; Biofarmaci; Biopharmaceutics;

    Sammanfattning : Pulmonary delivery of drugs is the preferred route of administration for treatment of local lung diseases like asthma and chronic obstructive pulmonary disease. Recently, there has also been increased interest in systemic delivery of drugs via the lungs to avoid problems with low and/or variable gastrointestinal absorption, and as a needle-free alternative for drugs that cannot be ingested. LÄS MER

  4. 3. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies

    Författare :Helena Anna Thörn; Hans Lennernäs; Paul Alfred Dickinson; Brian Houston; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. LÄS MER