Sökning: "topical delivery"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden topical delivery.
Sammanfattning : Water is a vital component regulating the properties of topical formulations and their interaction with biological barriers, such as skin and mucosa. Changing the watercontent within the frame of the pharmaceutical triangle will have a huge impact on which type of formulation, such as a cream, ointment, gel, or lotion, is formed, as well as the physical properties of the formulation. LÄS MER
Sammanfattning : The development of antimicrobial resistance is a great challenge within health sectors worldwide. Thus, demand for new, efficient treatments is urgent in order to treat various bacterial infections. Antimicrobial peptides (AMPs) are a group of antibiotics that have gained more and more attraction in the past decade. LÄS MER
3. Lipid based formulations for topical application: characterization and delivery of active substances
Sammanfattning : In this thesis, the interaction between lipids, solvents and active substances in lipid based formulations have been studied and related to formulation structure or release behavior on human skin or a model thereof. For the different investigations, isotropic equilibrium lipid phases, i.e. LÄS MER
Sammanfattning : Non-healing wounds is a growing medical problem, often associated with pathological conditions such as diabetes and peripheral ischemia. A non-healing wound entails a large amount of suffering for the patient, and demands extensive health care resources. LÄS MER
5. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems
Sammanfattning : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. LÄS MER