Sökning: "topical delivery"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden topical delivery.

  1. 1. Topical  formulations, design and drug delivery : "A dive into water"

    Författare :Abdullah Ali; Marie Lodén; Anan Yagmur; Anders Hall; Malmö universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; water; topical formulations; Pickering emulsion; skin cream; drug delivery; tactile friction; sensory panel; nasal; buccal; mucosa; skin; triglycerides; ethanol; drug transport; cosmetic appeal;

    Sammanfattning : Water is a vital component regulating the properties of topical formulations and their interaction with biological barriers, such as skin and mucosa. Changing the watercontent within the frame of the pharmaceutical triangle will have a huge impact on which type of formulation, such as a cream, ointment, gel, or lotion, is formed, as well as the physical properties of the formulation. LÄS MER

  2. 2. Lipid-based liquid crystals as drug delivery vehicles for antimicrobial peptides

    Författare :Lukas Boge; Martin Andersson; Lovisa Ringstad; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; infection; phase behavior; antimicrobial effect; Liquid crystals; hexosome; antimicrobial resistance; AMP; antimicrobial peptide; pulmonary delivery; topical delivery; glycerol monooleate; bacterial membrane; cubosome; liquid crystalline nanoparticles; membrane interaction; proteolysis;

    Sammanfattning : The development of antimicrobial resistance is a great challenge within health sectors worldwide. Thus, demand for new, efficient treatments is urgent in order to treat various bacterial infections. Antimicrobial peptides (AMPs) are a group of antibiotics that have gained more and more attraction in the past decade. LÄS MER

  3. 3. Lipid based formulations for topical application: characterization and delivery of active substances

    Författare :Johanna Bender; Chalmers University of Technology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bicontinuous cubic phase; phytantriol; passive diffusion; bicontinuous sponge phase; stratum corneum; W O microemulsion; monoolein; medium chain triglycerides;

    Sammanfattning : In this thesis, the interaction between lipids, solvents and active substances in lipid based formulations have been studied and related to formulation structure or release behavior on human skin or a model thereof. For the different investigations, isotropic equilibrium lipid phases, i.e. LÄS MER

  4. 4. Accelerated wound healing by on-site production and delivery of CXCL12

    Författare :Emelie Öhnstedt; Mia Phillipson; Uppsala universitet; []
    Nyckelord :wound healing; non-healing wounds; L. reuteri; macrophages; wound assessment; Fysiologi; Physiology;

    Sammanfattning : Non-healing wounds is a growing medical problem, often associated with pathological conditions such as diabetes and peripheral ischemia. A non-healing wound entails a large amount of suffering for the patient, and demands extensive health care resources. LÄS MER

  5. 5. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems

    Författare :Quoc Dat Pham; Fysikalisk kemi; []
    Nyckelord :stratum corneum; lipid; keratin filament; protein; DMPC; penetration enhancer; osmolyte; solvent; monoterpene; fatty acid; hydration; molecular mobility; fluidity; permeability; PT ssNMR; diffusion cell;

    Sammanfattning : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. LÄS MER