Sökning: "position accuracy"

Visar resultat 11 - 15 av 241 avhandlingar innehållade orden position accuracy.

  1. 11. Aspects of PET-CT in prostate cancer. Protocol optimization, diagnostic accuracy, and dosimetry

    Författare :Mimmi Bjöersdorff; Malmö Nuklearmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET-CT; Prostatacancer; [18F]FCH; [18F]PSMA-1007; optimering; diagnostisk noggrannhet; dosimetri; PET-CT; Prostate Cancer; [18F]FCH; [18F]PSMA-1007; Optimization; Diagnostic accuracy; Dosimetric;

    Sammanfattning : The PET-CT imaging modality is based on positron emission tomography combined with computed tomography. Before a PET-CT examination, a radioactive tracer (also called a radiopharmaceutical) is intravenously injected into the patient. PET technology images the distribution of this tracer element by detecting the decay. LÄS MER

  2. 12. Accuracy of mRNA Translation in Bacterial Protein Synthesis

    Författare :Jingji Zhang; Måns Ehrenberg; Olke C. Uhlenbeck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; genetic code; misreading; error hot spots; kinetics; aminoglycoside; Biokemi; Biochemistry;

    Sammanfattning : Reading of messenger RNA (mRNA) by aminoacyl-tRNAs (aa-tRNAs) on the ribosomes in the bacterial cell occurs with high accuracy. It follows from the physical chemistry of enzymatic reactions that there must be a trade-off between rate and accuracy of initial tRNA selection in protein synthesis: when the current accuracy, the A-value, approaches its maximal possible value, the d-value, the kinetic efficiency of the reaction approaches zero. LÄS MER

  3. 13. Rate and Accuracy of Bacterial Protein Synthesis with Natural and Unnatural Amino Acids

    Författare :Ka-Weng Ieong; Måns Ehrenberg; Simpson Joseph; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; protein synthesis; translation; efficiency-accuracy trade-off; kinetics; unnatural amino acids; Molecular Biology; Molekylärbiologi;

    Sammanfattning : This thesis addresses different questions regarding the rate, efficiency, and accuracy of peptide bond formation with natural as well as unnatural amino acids: Which step is rate-limiting during peptide bond formation? How does the accuracy vary with different transfer RNAs (tRNAs) and codons and how is it relevant to the living cells? Does proofreading selection of codon reading occur in a single- or multi-step manner as theoretically suggested? How does the E. coli translation system discriminate unnatural amino acids? Based on that, how to improve the incorporation efficiencies of unnatural amino acids?Based on the study on pH dependence of peptide bond formation, we show that the rate of the chemistry of peptidyl transfer to aminoacyl-tRNA (AA-tRNA) Gly-tRNAGly or Pro-tRNAPro limits the rate of peptide bond formation at physiological pH 7. LÄS MER

  4. 14. Assessment of acetabular cup position with computed tomography

    Författare :Henrik Olivecrona; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Revision of Total Hip Arthroplasty (THA) due to loosening is necessary in many patients. Diagnosis is usually late with significant bone and soft tissue destruction. Available diagnostic techniques are either not sensitive enough or too complicated and expensive for routine use. LÄS MER

  5. 15. Wireless esophageal PH monitoring. Clinical evaluation of a new technique

    Författare :Jörgen Wenner; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; orthopaedics; traumatology; Kirurgi; thresholds; specificity; sensitivity; diagnostic accuracy; adverse symptoms; wireless; pH monitoring; gastroesophageal reflux disease; ortopedi; traumatologi;

    Sammanfattning : Esophageal pH monitoring is important in the clinical management of patients with symptoms suggestive of gastroesophageal reflux disease (GERD), and in research aiming to clarify the mechanisms involved in the development of GERD complications. Catheter-based techniques for pH recording are uncomfortable, not well tolerated by all patients and cannot reliably measure acid exposure in the most distal esophagus the region most prone to reflux-induced complications. LÄS MER