Sökning: "pipecoloxylidide"

Hittade 3 avhandlingar innehållade ordet pipecoloxylidide.

  1. 1. Transition Metal- and Enzyme-Catalyzed Reactions of Primary Amines and Allylic Alcohols : Powerful Tools in the Preparation of Pharmaceutically Important Compounds

    Författare :Lisa K. Thalén; Jan-Erling Bäckvall; Dirk De Vos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dynamic kinetic resolution; racemization; catalysis; hydrogen transfer; kinetic resolution; norsertraline; alpha-methyl carboxylic acids; pipecoloxylidide; organisk kemi; Organic Chemistry;

    Sammanfattning : Dynamic kinetic resolution (DKR) has been applied to primary amines utilizing a ruthenium catalyst and an (R)-selective lipase to provide the corresponding amides in up to 95% isolated yield and up to >99% ee. Further investigations of the chemoenzymatic DKR of amines show that it is general and can be applied to a wide range of amines. LÄS MER

  3. 2. Drug Transport and Metabolism in Rat and Human Intestine

    Författare :Sofia Berggren; Hans Lennernäs; Janet Hoogstraate; Patrick Augustijns; Uppsala universitet; []
    Nyckelord :Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

    Sammanfattning : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. LÄS MER

  4. 3. Exploratory clinical development of ropivacaine, a local anaesthetic, in ulcerative colitis

    Författare :Eva Arlander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug development; ulcerative colitis; ropivacaine; rectal administration; pharmacokinetics; metabolism.;

    Sammanfattning : The aims of this thesis were to explore the clinical pharmacology of ropivacaine gel as a potential new rectal therapy for ulcerative colitis (UC). The studies included pharmacokinetics, tolerability, preliminary efficacy in patients, formulation factors and drug-drug interactions. LÄS MER