Sökning: "microsome"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet microsome.
1. Drug Transport and Metabolism in Rat and Human Intestine
Sammanfattning : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. LÄS MER
2. Metabolite Profiling of Drugs using Mass Spectrometry : Identification of analytical targets for doping control and improvements of the metabolite search process
Sammanfattning : Doping is defined as the use of prohibited substances or methods by the World Anti-Doping Agency and the aim with doping control analysis is to detect the use of these illicit substances or methods. Substances that are prohibited in human or equine sports have either a positive or negative impact on the performance. LÄS MER
3. Chemical analysis of complex mixtures with regard to potentially genotoxic organic compounds
Sammanfattning : This thesis describes different methods for the extraction, fractionation, and analysis of particle adsorbed organic compounds. The utility of capillary gas chromatography mass spectrometry (GC-MS) for the analysis of polycyclic aromatic compounds (PAC) is demonstrated. LÄS MER
4. Genotoxic hazards in the rubber industry : application of short-term tests in work environment analyses
Sammanfattning : Excess mortality from a number of different types of cancer has been associated with work in the rubber industry. The aim of the present study - using short-term tests for mutagenicity - was to identify potentially hazardous additives and process fumes to which workers are exposed. LÄS MER
5. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic
Sammanfattning : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. LÄS MER