Sökning: "physiologically based toxicokinetic model"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden physiologically based toxicokinetic model.

  1. 1. Physiologically based pharmacokinetic modeling in risk assessment - Development of Bayesian population methods

    Författare :Fredrik Jonsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; methyl chloride; dichloromethane; toluene; styrene; uncertainty; intra- individual variability; risk assessment; physiologically based modeling; Markov chain Monte Carlo; PBPK; Bayesian; population modeling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Sammanfattning : In risk assessment of risk chemicals, variability in susceptibility in the population is an important aspect. The health hazard of a pollutant is related to the internal exposure to the chemical, i.e. the target dose, rather than the external exposure. LÄS MER

  2. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    Författare :Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Sammanfattning : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. LÄS MER

  3. 3. Improved scientific basis for human health risk assessment factors by toxicokinetic population modeling

    Författare :Anna-Karin Mörk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Exposure limits or guidelines are derived to protect humans from adverse effects caused by exposure to chemical substances in the environment or at the workplace. The internal dose of a chemical is determined by toxicokinetic (TK) processes such as uptake, distribution and elimination, and is closely related to the risk of adversity. LÄS MER

  4. 4. Ethers as gasoline additives : toxicokinetics and acute effects in humans

    Författare :Annsofi Nihlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; acute effects; biological monitoring; ethyl tertiary-butyl ether; ETBE; man; methyl tertiary-butyl ether; MTBE; oxygenate; petrol; physiologically based toxicokinetic model; PBTK; PBPK; tertiary-butyl alcohol; TBA; toxicokinetics;

    Sammanfattning : Ethers or other oxygen-containing compounds are used as replacements for lead in gasoline and to ensure complete combustion. Methyl tertiary-butyl ether (MTBE) is already in use world-wide and ethyl tertiary-butyl ether (ETBE) may be used increasingly in the future. LÄS MER

  5. 5. Cyanide in breath as a marker for cyanide poisoning

    Författare :Kristin Stamyr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Approximately 120 people die every year due to fires in Sweden. A majority of the fire victims die due to toxic fire gases. Carbon monoxide is often thought to be the major cause of death. Still, another very toxic fire gas, hydrogen cyanide, is formed when materials containing nitrogen burn, e. LÄS MER