Sökning: "interspecies scaling"
Hittade 4 avhandlingar innehållade orden interspecies scaling.
1. Pharmacometric tools to support translational drug development
Sammanfattning : The use of model-informed drug development has been shown to save significant costs and improve decision making early in the drug development process. The work in this PhD thesis aimed to employ pharmacometric tools to support translational drug development from the preclinical to the late clinical stages. LÄS MER
2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection
Sammanfattning : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. LÄS MER
3. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis
Sammanfattning : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. LÄS MER
4. Extracellular electron transfer features of the Gram-positive bacterium Enterococcus faecalis
Sammanfattning : Electroactive microorganisms possess the unique ability to transfer electrons to or from a solid phase electron conductor, e.g., electrodes or minerals, through various physiological mechanisms. LÄS MER