Sökning: "interspecies scaling"

Hittade 4 avhandlingar innehållade orden interspecies scaling.

  1. 1. Pharmacometric tools to support translational drug development

    Författare :Rami Ayoun Alsoud; Ulrika S. H. Simonsson; Michael Lyons; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug development; pharmacometrics; pharmacokinetics; pharmacodynamics; non-linear mixed effect models; tuberculosis; dose selection; interspecies scaling; pediatric trials; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The use of model-informed drug development has been shown to save significant costs and improve decision making early in the drug development process. The work in this PhD thesis aimed to employ pharmacometric tools to support translational drug development from the preclinical to the late clinical stages. LÄS MER

  3. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    Författare :Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Sammanfattning : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. LÄS MER

  4. 3. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis

    Författare :Oskar Alskär; Maria C Kjellsson; Mats O Karlsson; Jenny Y. Chien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; pharmacometrics; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. LÄS MER

  5. 4. Extracellular electron transfer features of the Gram-positive bacterium Enterococcus faecalis

    Författare :Galina Pankratova; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gram-positive bacteria; Enterococcus faecalis; Extracellular electron transfer; Electron-conducting redox polymers; Mediated electron transfer;

    Sammanfattning : Electroactive microorganisms possess the unique ability to transfer electrons to or from a solid phase electron conductor, e.g., electrodes or minerals, through various physiological mechanisms. LÄS MER