Sökning: "Patrik L. Andersson"

Hittade 5 avhandlingar innehållade orden Patrik L. Andersson.

  1. 1. Development of in silico methods to aid chemical risk assessment : focusing on kinetic interactions in mixtures

    Författare :Elena Golosovskaia; Patrik L. Andersson; Stefan Örn; Patrik Rydén; Ester Papa; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QSAR; physiologically based kinetic; PBK; zebrafish; ADME; mixture; bisphenols; PFAS; toxicokinetics; environmental science; miljövetenskap; Toxicology; toxikologi;

    Sammanfattning : The environment and biota are constantly exposed to numerous chemicals through contaminated food, soil, water, and air. These chemicals can be taken up and distributed to reach sensitive tissues where they may cause various effects. Many of these chemicals lack data on their environmental and human health effects. LÄS MER

  2. 2. Use and Development of Diffusive Samplers to Analyse the Fate of Polycyclic Aromatic Compounds, Polychlorinated Biphenyls and Pharmaceuticals in Wastewater Treatment Processes

    Författare :Lijana Augulyte; Patrik L. Andersson; Anna Ledin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioavailable; biologically activated carbon; PRCs; sampling rate; SPMD; sorption; wastewater treatment; diffusive passive samplers; human pharmaceuticals; municipal sewage treatment plant; organic micropollutants; polycyclic aromatic compounds; PAHs; PCBs; POCIS; Environmental chemistry; Miljökemi;

    Sammanfattning : The efficiency of wastewater treatment systems is commonly measured by the reductions of parameters such as biological oxygen demand (BOD), chemical oxygen demand (COD) and total suspended solids (TSS) and/or reductions in levels of selected macro compounds (e.g. long-chained hydrocarbons and inorganic compounds). LÄS MER

  3. 3. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)

    Författare :Ioana C. Chelcea; Patrik L. Andersson; Timo Hamers; Jessica Legradi; Stefan Örn; Carolina Vogs; Nynke Kramer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PBTK; Toxicokinetics; Endocrine disruptors; bisphenols; zebrafish; embryo; Toxicology; toxikologi;

    Sammanfattning : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. LÄS MER

  4. 4. Persistency, bioaccumulation and toxicity assessment of selected brominated flame retardants

    Författare :Jenny Rattfelt Nyholm; Patrik L. Andersson; Peter Haglund; Mats Tysklind; Walter Vetter; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; persistence; bioaccumulation; toxicity; biodegradation; biotransformation; PBT; read across; soil; earthworm; zebrafish; copepod; BFRs; polybrominated diphenyl ethers; tetrabromobisphenol A; hexabromocyclododecane; hexabromobenzene; 2; 4; 6-tribromophenol; tetrabromobisphenol A; 2-hydroxyethyl ether; 1; 2-dibromo-4- 1; 2-dibromoethyl cyclohexane; Environmental chemistry; Miljökemi;

    Sammanfattning : Brominated flame retardants (BFRs) are chemicals used in e.g. electronic equipment, textiles and plastics for the prevention of fire. Over recent decades, concern has been raised regarding some heavily used BFRs, since the levels in the environment have been increasing. LÄS MER

  5. 5. Improving alternatives assessment of plastic additives : exploring in silico tools to identify less hazardous flame retardants

    Författare :Ziye Zheng; Patrik L. Andersson; Hans Peter Arp; Gregory Peters; Gerrit Schüürmann; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chemical alternatives assessment; plastic additives; flame retardants; hazard; emission; in silico; modeling; quantitative structure-activity relationship QSAR ; multi-criteria decision analysis MCDA ; environmental science; miljövetenskap; organisk kemi; Organic Chemistry; ekotoxikologi; Ecotoxicology; Toxicology; toxikologi;

    Sammanfattning : Alternatives assessment is applied for replacing hazardous chemicals with viable, safer substitutes. High quality experimental hazard data, however, are usually unavailable for this purpose, and obtaining in silico data is the only approach to fill in data gaps. LÄS MER