Sökning: "PBTK"

Hittade 3 avhandlingar innehållade ordet PBTK.

  1. 1. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)

    Författare :Ioana C. Chelcea; Patrik L. Andersson; Timo Hamers; Jessica Legradi; Stefan Örn; Carolina Vogs; Nynke Kramer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PBTK; Toxicokinetics; Endocrine disruptors; bisphenols; zebrafish; embryo; Toxicology; toxikologi;

    Sammanfattning : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. LÄS MER

  3. 2. Ethers as gasoline additives : toxicokinetics and acute effects in humans

    Författare :Annsofi Nihlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acute effects; biological monitoring; ethyl tertiary-butyl ether; ETBE; man; methyl tertiary-butyl ether; MTBE; oxygenate; petrol; physiologically based toxicokinetic model; PBTK; PBPK; tertiary-butyl alcohol; TBA; toxicokinetics;

    Sammanfattning : Ethers or other oxygen-containing compounds are used as replacements for lead in gasoline and to ensure complete combustion. Methyl tertiary-butyl ether (MTBE) is already in use world-wide and ethyl tertiary-butyl ether (ETBE) may be used increasingly in the future. LÄS MER

  4. 3. Fluorinated hydrocarbons used as refrigerants : toxicokinetics and effects in humans

    Författare :Sara Gunnare; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hydrofluorocarbons (HFCs) and hydrochlorofluorocarbons (HCFCs) have replaced the chlorofluorocarbons (CFCs) in refrigeration installations and air-conditioning applications. As substitution progressed, some refrigeration mechanics experienced symptoms of inflammation. LÄS MER