Sökning: "toxicokinetics"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet toxicokinetics.

  1. 1. Toxicokinetics of inhaled trimethylbenzenes in man

    Författare :Jill Järnberg; Uppsala universitet; []
    Nyckelord :Medical sciences; trimethylbenzene; dimethylhippuric acid; white spirit; toxicokinetics; biological monitoring; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; arbets- och miljömedicin; Occupational and Environmental Medicine;

    Sammanfattning : In the toxicological risk assessment, data on the uptake and disposition (toxicokinetics) of the chemical is important. The three isomeric trimethylbenzenes (TMBs) are widely used as components in solvent mixtures and motor fuels. LÄS MER

  3. 2. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)

    Författare :Ioana C. Chelcea; Patrik L. Andersson; Timo Hamers; Jessica Legradi; Stefan Örn; Carolina Vogs; Nynke Kramer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PBTK; Toxicokinetics; Endocrine disruptors; bisphenols; zebrafish; embryo; Toxicology; toxikologi;

    Sammanfattning : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. LÄS MER

  4. 3. Development of in silico methods to aid chemical risk assessment : focusing on kinetic interactions in mixtures

    Författare :Elena Golosovskaia; Patrik L. Andersson; Stefan Örn; Patrik Rydén; Ester Papa; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QSAR; physiologically based kinetic; PBK; zebrafish; ADME; mixture; bisphenols; PFAS; toxicokinetics; environmental science; miljövetenskap; Toxicology; toxikologi;

    Sammanfattning : The environment and biota are constantly exposed to numerous chemicals through contaminated food, soil, water, and air. These chemicals can be taken up and distributed to reach sensitive tissues where they may cause various effects. Many of these chemicals lack data on their environmental and human health effects. LÄS MER

  5. 4. Ethers as gasoline additives : toxicokinetics and acute effects in humans

    Författare :Annsofi Nihlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acute effects; biological monitoring; ethyl tertiary-butyl ether; ETBE; man; methyl tertiary-butyl ether; MTBE; oxygenate; petrol; physiologically based toxicokinetic model; PBTK; PBPK; tertiary-butyl alcohol; TBA; toxicokinetics;

    Sammanfattning : Ethers or other oxygen-containing compounds are used as replacements for lead in gasoline and to ensure complete combustion. Methyl tertiary-butyl ether (MTBE) is already in use world-wide and ethyl tertiary-butyl ether (ETBE) may be used increasingly in the future. LÄS MER

  7. 5. Fluorinated hydrocarbons used as refrigerants : toxicokinetics and effects in humans

    Författare :Sara Gunnare; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hydrofluorocarbons (HFCs) and hydrochlorofluorocarbons (HCFCs) have replaced the chlorofluorocarbons (CFCs) in refrigeration installations and air-conditioning applications. As substitution progressed, some refrigeration mechanics experienced symptoms of inflammation. LÄS MER