Sökning: "Endocrine disruptors"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Endocrine disruptors.

  1. 1. Reproductive toxicology of endocrine disruptors : effects of cadmium, phthalates and phytoestrogens on testicular steroidogenesis

    Författare :David Gunnarsson; Gunnar Selstam; Gunnar Nordberg; Per Leffler; Henrik Leffers; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrine disruptors; reproductive toxicology; cadmium; phthalates; DEHP; MEHP; phytoestrogens; steroidogenesis; testosterone; Leydig cell; Molecular biology; Molekylärbiologi;

    Sammanfattning : A number of investigations during the last two decades describe adverse trends in male reproductive health, which have been proposed to be caused by environmental factors with endocrine disrupting properties. In contrast to many other toxicants, endocrine disruptors often do not show linear dose-response relationships typical of those found in traditional toxicological studies. LÄS MER

  2. 2. Effects of some Endocrine Disruptors on Human and Grey Seal Uterine Cells

    Författare :Carolina Bredhult; Matts Olovsson; Britt-Marie Bäcklin; Olle Söder; Uppsala universitet; []
    Nyckelord :Obstetrics and gynaecology; Reproductive toxicology; Baltic grey seal; leiomyoma; myometrial cells; endometrial endothelial cells; hormones; endocrine disruptors; Obstetrik och kvinnosjukdomar;

    Sammanfattning : The effects of environmental contaminants in humans and animals are of great concern. Some contaminants are endocrine disruptors that may interfere with the endogenous hormonal signalling and disturb, for example, reproductive organs and functions. LÄS MER

  3. 3. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

    Författare :Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Sammanfattning : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. LÄS MER

  4. 4. Endocrine Disruption in Amphibians : Developmental Effects of Ethynylestradiol and Clotrimazole on the Reproductive System

    Författare :Irina Gyllenhammar; Cecilia Berg; Ingvar Brandt; Lena Holm; Joakim Larsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Test system; Xenopus tropicalis; Rana temporaria; sex ratio; sex differentiation; fertility; aromatase; ovary; testis; oviduct; Biology; Biologi;

    Sammanfattning : Amphibian populations are declining world-wide and one of the suggested reasons is environmental pollutants. Studies of long-term effects on the reproductive system in frogs following larval exposure to environmental pollutants are scarce. It is therefore important to develop methods to study developmental reproductive toxicity in amphibians. LÄS MER

  5. 5. In vitro and in vivo studies on the toxicology of di-n-butyl phthalate (DBP) : Effects on reproductive, endocrine, and immune systems

    Författare :Liselott Källsten; Oskar Karlsson; Paula Pierozan; Jonathan W. Martin; Jorma Toppari; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dibutyl phthalate; Endocrine disrupting chemicals; Male reproductive health; Phthalates; Immunotoxicity; Toxicology; Steroidogenesis; Environmental Sciences; miljövetenskap;

    Sammanfattning : Chemical pollution is an increasing societal problem and has a major impact on human and environmental health. One important source of chemical pollution is plastic, which contains many different compounds with often largely unknown hazards. LÄS MER