Sökning: "CMS"
Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet CMS.
1. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections
Sammanfattning : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. LÄS MER
2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection
Sammanfattning : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. LÄS MER
3. Development of Accurate Reduced Order Models in a Simulation Tool for Turbomachinery Aeromechanical Phenomena
Sammanfattning : Modern gas turbines are still vulnerable to vibrations when operated at certain speeds. This unstable environment can lead to high cycle fatigue (HCF) and damage several of the components inside the turbine. LÄS MER
4. Load and risk based maintenance management of wind turbines
Sammanfattning : Wind power has proven to be an important source of renewable energy in the modern electric power systems. Low profit margins due to falling electricity prices and high maintenance costs, over the past few years, have led to a focus on research in the area of maintenance management of wind turbines. LÄS MER
5. Load and Risk Based Maintenance Management of Wind Turbines
Sammanfattning : The cost of maintenance is a considerable part of the total life cycle cost in wind turbines, especially for offshore applications. Research has shown that some critical components account for most of the downtime in the wind turbines. LÄS MER