Sökning: "pharmacokinetics skin"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden pharmacokinetics skin.

  1. 6. Procedural and postoperative pain-reducing methods in newborns

    Författare :Björn A Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Analgesia; anaesthesia; topical; local; epidural; lidocame; prilocaine; bupivacame; venepuncture; heel-lancing; skin thickness; skin perfusion; infant; neonate;

    Sammanfattning : The neonate has a functioning nociceptive system. However, neonates are probably more vulnerable than the older infants and adults to the negative effects of pain. Untreated pain and stress stimuli may have long-term effects. It is, therefore, very important to find ways to reduce pain and painful stimuli in neonates. LÄS MER

  3. 7. On paediatric regional anaesthesia : the use of paravertebral blockade, aspects on plasma protein binding, and systemic toxicity of local anaesthetics

    Författare :Per-Arne Lönnqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Anesthesia; regional; paravertebral Children; infants Local anesthetics; bupivacaine; lidocaine Pharmacokinetics Plasma protein binding Side effects Toxicity.PA Lönnqvist: On paediatric regional anaesthesia: The use of paravertebral blockade; aspec;

    Sammanfattning : Paediatric regional anaesthesia has gained widespread popularity during recent years because of an excellent potential for intra- and postoperative pain relief and reduction of the surgically induced stress response. The aim of the present thesis was to adapt and develop the technique of paravertebral blockade (PVB) for the safe use in paediatric patients and also to investigate aspects on plasma protein binding and toxicity of local anaesthetic drugs which might be of importance in the special settings of paediatric anaesthesia. LÄS MER

  4. 8. Spectroscopic techniques for photodynamic therapy dosimetry

    Författare :Ann Johansson; Atomfysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Atomic and molecular physics; diffuse light spectroscopy; photodynamic therapy; biomedical optics; Atom- och molekylärfysik;

    Sammanfattning : Photodynamic therapy (PDT) as a cancer treatment modality relies on the simultaneous presence of three components; light, photosensitiser and oxygen. Once excited by the light, the photosensitiser can interact with oxygen, leading to the formation of toxic oxygen species. LÄS MER

  5. 9. Toxicity and pharmacokinetic biomarkers for personalized non-small cell lung cancer treatment

    Författare :Anna Svedberg; Henrik Green; Svante Vikingsson; Joakim Lundeberg; Mikko Niemi; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Lung cancer is the leading cause of cancer-related deaths worldwide. Unfortunately, lung cancer is usually discovered at a late stage when the curative treatment options are limited. The treatment can include surgery, radiation, chemotherapy, targeted therapy and now also immunotherapy. LÄS MER

  7. 10. ARCON in experimental and clinical radiotherapy

    Författare :Ana Maria Rojas Callejas; Björn Zackrisson; René-Olivier Mirimanoff; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; ARCON; tumours; normal tissues; radiosensitization; carbogen; nicotinamide; repair inhibition; therapeutic gain; rodents; humans; Onkologi; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. LÄS MER