Sökning: "melanocytes"
Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet melanocytes.
1. Vitiligo and Piebaldism : Treatmant of Leucoderma by Transplantation of autologous melanocytes
Sammanfattning : Background: Vitiligo and piebaldism are disorders in which the affected skin lack epidermal melanocytes. Vitiligo is acquired and can clinically be subgrouped, but the aetiology is still not fully understood. The most common type, generalized vitiligo (vitiligo vulgaris) has autoimmune involvement and affects about 1. LÄS MER
2. Epidermal Melanocyte Response to Radiotherapy
Sammanfattning : Cutaneous interfollicular melanocytes protect the skin from UV-radiation (UVR), and their response to UVR is well established. To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy (RT) has not been explored. LÄS MER
3. Identification and clinical evaluation of senescence-associated markers to distinguish melanocytic nevi from melanomas
Sammanfattning : Melanoma is a form of cancer that develops in melanocytes. While it represents only 5% of skin malignancies, it is the most aggressive and lethal. Benign proliferation of these cells form the melanocytic nevi. The definitive diagnosis of melanocytic nevi or melanoma lesions is histopathologic. LÄS MER
4. Antibody-based Profiling of Expression Patterns using Cell and Tissue Microarrays
Sammanfattning : In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell lines, a cell microarray (CMA) was developed, facilitating antibody-based protein profiling of cell lines using immunohistochemistry (IHC). LÄS MER
5. Regulation of UV induced apoptosis in human melanocytes
Sammanfattning : Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every 10-20 years. LÄS MER