Sökning: "pancreatic islet transplantation"

Visar resultat 31 - 35 av 43 avhandlingar innehållade orden pancreatic islet transplantation.

  1. 31. Role of Thrombospondin-1 in Endogenous and Transplanted Pancreatic Islets

    Författare :Johan Olerud; Per-Ola Carlsson; Nils Welsh; Leif Jansson; Thierry Berney; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Type 1 diabetes mellitus is a severe life-long disease with a pronounced risk of developing secondary complications. One way to avoid the latter is to restore the fine tuning of blood glucose homeostasis by transplantation of pancreatic islets. LÄS MER

  3. 32. Modulation of the Immune Response in Concordant Xenotransplantation

    Författare :Adam Bersztel; Gunnar Tufveson; Michael Olausson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Antibodies; blood transfusions; heart; pancreatic islets; tolerance; xenotransplantation; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Xenotransplantation, i.e. transplantation between different species, could be a possible solution to the present shortage of organ donors. The immunological response to a xenograft is strong and difficult to suppress. LÄS MER

  4. 33. Positron Emission Tomography and Magnetic Resonance Techniques in Diabetes

    Författare :Lina Carlbom; Håkan Ahlström; Olle Korsgren; Olof Eriksson; Lars Johansson; Tove Grönroos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; Magnetic resonance imaging; Magnetic resonance spectroscopy; Type 1 diabetes; Type 2 diabetes; PET MR; Pancreas transplantation; Perfusion; Radiology; Radiologi;

    Sammanfattning : In order to further advance the field of diabetes research there is a great need for establishing validated non-invasive quantitative techniques to study the pancreas and other tissues of importance for blood glucose regulation. The general aim of this thesis was to explore magnetic resonance techniques and positron emission tomography as such tools. LÄS MER

  5. 34. Role of Islet Endothelial Cells in β-cell Function and Growth

    Författare :Magnus Johansson; Leif Jansson; Per-Ola Carlsson; Lena Holm; Susan Bonner-Weir; Uppsala universitet; []
    Nyckelord :Cell biology; Cellbiologi;

    Sammanfattning : The pancreatic islets are collections of endocrine cells, dispersed throughout the pancreas. In adult islets, endocrine cells are closely associated with capillary endothelial cells and receive a high blood perfusion. Transplanted pancreatic islets, on the other hand, have a vascular disturbance, manifested as decreased blood vessel density. LÄS MER

  7. 35. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function

    Författare :Magdalena Mazur; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas development; beta cells; insulin; MafA; MafB; Mitf; diabetes;

    Sammanfattning : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. LÄS MER