Sökning: "heart"

Visar resultat 1 - 5 av 1752 avhandlingar innehållade ordet heart.

  1. 1. Heart failure : biomarker effect and influence on quality of life

    Författare :Patric Karlström; Urban Alehagen; Mikael Dellborg; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart failure; Biomarker; B-type natriuretic peptide; Heart failure treatment; B-type Natriuretic Peptide guided heart failure treatment; Responders; Health-related quality of life; Heart failure duration; Outcomes;

    Sammanfattning : Background and aims: Heart failure (HF) is a life threatening condition and optimal handling is necessary to reduce risk of therapy failure. The aims of this thesis were: (Paper I) to examine whether BNP (B-type natriuretic peptide)-guided HF treatment improves morbidity and mortality when compared with HF therapy implemented by a treating physician at sites experienced in managing patients with HF according to guidelines; (Paper II) to investigate how to define a responder regarding optimal cut-off level of BNP to predict death, need for hospitalisation, and worsening HF and to determine the optimal time to apply the chosen cut-off value; (Paper III) to evaluate how Health-Related Quality of Life (HR-QoL) is influenced by natriuretic peptide guiding and to study how HR-QoL is affected in responders compared to non-responders; (Paper IV) to evaluate the impact of patient age on clinical outcomes, and to evaluate the impact of duration of the HF disease on outcomes and the impact of age and HF duration on BNP concentration. LÄS MER

  2. 2. Heart Regeneration : Lessons from the Red Spotted Newt

    Författare :Nevin Witman; Jamie Morrison; Thomas Braun; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Heart; Regeneration; Newt; microRNAs; RNA editing; molekylärbiologi; Molecular Biology;

    Sammanfattning : Unlike mammals, adult salamanders possess an intrinsic ability to regenerate complex organs and tissue types, making them an exciting and useful model to study tissue regeneration. The aims of this thesis are two fold, (1) to develop and characterize a reproducible cardiac regeneration model system in the newt, and (2) to decipher the cellular and molecular underpinnings involved in regeneration. LÄS MER

  3. 3. Heart preservation

    Författare :Guangqi Qin; Thoraxkirurgi; []

    Sammanfattning : In clinical transplantation today, the donor heart is preserved with cold ischemic storage that gives safe preservation for 4 hours. Non-ischemic perfusion preservation is able to preserve the donor heart for 24 hours in pre-clinical studies. The aim of this thesis is to investigate: 1. LÄS MER

  4. 4. Heart Valve Surgery : Preoperative Assessment and Clinical Outcome

    Författare :Laila Hellgren; Elisabeth Ståhle; Mårten Rosenquist; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Heart valve surgery; magentic resonance imaging; echocardiography; operative mortality; survival; complications; quality of life; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : A more global analysis of the outcome of heart valve surgery is desirable to reflect the actual benefit for the patient. This thesis focuses on the preoperative assessment of the patient, and the outcome after surgery with regard to operative mortality, long-term survival, valve-related complications, and quality of life. LÄS MER

  5. 5. Echocardiographic measurements of the heart : with focus on the right ventricle

    Författare :Karin Loiske; Kent Emilsson; Allan Sirsjö; Jan Engvall; Örebro universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Echocardiography; heart; right ventricle; right ventricular outflow tract 1; isovolumetric relaxation time; maximal early diastolic relaxation velocity; takotsubo cardiomyopathy; long-axis function; MEDICINE; MEDICIN; Clinical physiology; Klinisk fysiologi; Biomedicin; Biomedicine;

    Sammanfattning : Echocardiography is a well established technique when evaluating the size and function of the heart. One of the most common ways to measure the size of the right ventricle (RV) is to measure the RV outflow tract 1(RVOT1). Several ways to measure RVOT1 are described in the literature. LÄS MER