Sökning: "oligonucleotide"

Visar resultat 11 - 15 av 151 avhandlingar innehållade ordet oligonucleotide.

1. 11. Naturally derived cell-penetrating peptides and applications in gene regulation : A study on internalization mechanisms and endosomal escape

   Författare :Pontus Lundberg; Ülo Langel; Bernard Lebleu; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; endocytosis; gene regulation; Neurochemistry; Neurokemi;

   Sammanfattning : Cell-penetrating peptides are a class of peptides which have achieved a lot of recognition due to their vector abilities. Since their discovery over a decade ago, there has been an uncertainty concerning the mechanism by which they are internalized into the cells. LÄS MER

3. 12. Synthesis, Characterisation and Application of 68Ga-labelled Macromolecules

   Författare :Irina Velikyan; Bengt Långström; Mats Bergström; Helmut Maecke; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; 68Ga; 68Ge 68Ga generator; radiolabelling; microwave heating; specific radioactivity; peptide; protein; antibody; oligonucleotide; positron emission tomography; tumour; Kemi; Chemistry; Kemi;

   Sammanfattning : The positron emitting radionuclide 68Ga (T1/2 = 68 min) might become of practical interest for clinical positron emission tomography (PET). The metallic cation, 68Ga(III), is suitable for complexation with chelators, either naked or conjugated with biological macromolecules. LÄS MER

4. 13. Cell-penetrating peptides for oligonucleotide delivery : Design and uptake mechanisms

   Författare :Staffan Lindberg; Ülo Langel; Arwyn Jones; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; gene therapy; scavenger receptors; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The use of oligonucleotides for gene therapy has the potential to efficiently treat a plethora of diseases with minimal side effects. However, the use of oligonucleotides is hampered by the properties of these molecules, which make it essentially impossible for them to permeate the cellular membrane. LÄS MER

5. 14. Oligonucleotide Complexes with Cell-Penetrating Peptides : Structure, Binding, Translocation and Flux in Lipid Membranes

   Författare :Luis Daniel Ferreira Vasconcelos; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; Large unilamellar vesicle; Membrane perturbation; Endosomal escape; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The ability of cell-penetrating peptides to cross plasma membranes has been explored for various applications, including the delivery of bioactive molecules to inhibit disease-causing cellular processes. The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. LÄS MER

7. 15. Cell-penetrating peptides and oligonucleotide delivery

   Författare :Andrés Muñoz-Alarcón; Ülo Langel; Astrid Gräslund; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : .... LÄS MER