Sökning: "specific radioactivity"

Visar resultat 1 - 5 av 52 avhandlingar innehållade orden specific radioactivity.

1. 1. Synthesis of 11C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods

   Författare :Jonas Eriksson; Bengt Långström; Philip H. Elsinga; Uppsala universitet; []
   Nyckelord :Organic chemistry; isotopic labelling; carbon-11; alkyl iodides; acrylamides; specific radioactivity; carbonylation; carbon monoxide; non-thermal plasma; PET; Organisk kemi;

   Sammanfattning : Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. LÄS MER

3. 2. Synthesis, Characterisation and Application of 68Ga-labelled Macromolecules

   Författare :Irina Velikyan; Bengt Långström; Mats Bergström; Helmut Maecke; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; 68Ga; 68Ge 68Ga generator; radiolabelling; microwave heating; specific radioactivity; peptide; protein; antibody; oligonucleotide; positron emission tomography; tumour; Kemi; Chemistry; Kemi;

   Sammanfattning : The positron emitting radionuclide 68Ga (T1/2 = 68 min) might become of practical interest for clinical positron emission tomography (PET). The metallic cation, 68Ga(III), is suitable for complexation with chelators, either naked or conjugated with biological macromolecules. LÄS MER

4. 3. Novel allergen preparations for use in allergen-specific immunotherapy

   Författare :Theresa Neimert Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Allergy; allergen-specific immunotherapy; adjuvants; carbohydrate-based particles; allergic asthma; mouse models; hypoallergens;

   Sammanfattning : Allergy is a common disease in the industrialized countries, affecting approximately 25% of the population. Therefore, there is a need to find new treatment strategies to improve the quality of life for allergic individuals. Today the only treatment that gives long-lasting reduction of allergic symptoms is allergen-specific immunotherapy (SIT). LÄS MER

5. 4. Element transport in marine coastal ecosystems – modelling general and element-specific mechanisms

   Författare :Lena Konovalenko; Clare Bradshaw; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Modelling; bioaccumulation; concentration ratio; radionuclides; marine foodweb.; Marine Ecology; marin ekologi;

   Sammanfattning : Understanding the behaviour of naturally-occurring and anthropogenically-derived radionuclides (isotopes) in the marine environment is important, because there is a need for their effective utilization either as in situ tracers or for industry, medical applications, the planning of waste-disposal facilities, and estimations of human and animal health risks. Radionuclides generally have the same chemical properties as their stable element analogues and thus show similar environmental behaviour and cycling to their stable counterparts. LÄS MER

7. 5. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

   Författare :Camilla Hofström; Torbjörn Gräslund; Serge Muyldermans; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER