Sökning: "neurotrophin 3"

Visar resultat 6 - 10 av 44 avhandlingar innehållade orden neurotrophin 3.

  1. 6. Autoimmune and innate inflammation in the nervous system : neurotrophin production and impact on neuronal survival

    Författare :Cecilia Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurodegeneration; autoimmunity; neurotrophin; motoneuron; cytokine; axotomy;

    Sammanfattning : The occurrence of a continuous immune surveillance in the central nervous system (CNS) is a fairly recent finding. For long the CNS was considered an immune privileged organ, with the blood-brain barrier constituting an effective barrier against blood-derived molecules and cells. LÄS MER

  3. 7. TNF-α and neurotrophins in Achilles tendinosis

    Författare :Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Sammanfattning : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. LÄS MER

  4. 8. Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression

    Författare :Anders Edsjö; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; oncology; cancerology; Cytology; N-myc.; trkC; trkB; trkA; neurotrophins; Neuroblastoma; sympathetic nervous system;

    Sammanfattning : Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. LÄS MER

  5. 9. Spinal cord injury : mechanical and molecular aspects

    Författare :Anna Josephson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; syringomyelia; MRI; fMRI; neurotrophin; Nogo; Nogo receptor; regulation;

    Sammanfattning : Traumatic spinal cord injury leads to full or partial paralysis and loss of sensation below the level of injury. The annual incidence of spinal cord injury in the United States is 3-5 per 100,000 and in Sweden is 1.5-2 per 100,000. This translates to 11,000 new cases of traumatic spinal cord injury in the US and 150 in Sweden each year. LÄS MER

  7. 10. Trophic factors, neuroprotection and spinal cord repair

    Författare :Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Sammanfattning : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. LÄS MER