Sökning: "trkB"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet trkB.

  1. 1. Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression

    Författare :Anders Edsjö; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; oncology; cancerology; Cytology; N-myc.; trkC; trkB; trkA; neurotrophins; Neuroblastoma; sympathetic nervous system;

    Sammanfattning : Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. LÄS MER

  3. 2. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

  4. 3. Factors influencing the turnover of olfactory receptor neurons

    Författare :Maja-Lena Deckner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :immunohistochemistry; in situ hybridization; rat; olfactory bulb; olfactory epithelium; axotomy; regeneration; apoptosis; BBB; VEGF; blood vessels; trophic factor; BDNF; trkB; tenascin;

    Sammanfattning : The olfactory system has a striking capacity for neuronal plasticity throughout life and the olfactory epithelium is able to generate both neuronal and non-neuronal cells in the normal adult animal as well as after experimental injury. In contrast to primary sensory neurons, olfactory axons are able to cross the border between the PNS and CNS in the olfactory bulb after transection in the adult animal. LÄS MER

  5. 4. Inhibition in cognition : neurophysiology and connectivity of gabaergic interneurons in the prefrontal cortex

    Författare :Josina Anna van Lunteren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prefrontal cortex (PFC) is a cortical region involved in higher-order cognitive functions, it is widely connected to the rest of the neocortex and is involved in tasks that require temporal integration of information. The local PFC circuit contains excitatory pyramidal neurons and inhibitory interneurons, and the interplay between these is essential for computations in the PFC. LÄS MER

  7. 5. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

    Författare :Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

    Sammanfattning : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. LÄS MER