Sökning: "nerve lesion"

Visar resultat 21 - 25 av 64 avhandlingar innehållade orden nerve lesion.

1. 21. On laminins and laminin receptors and their roles in regeneration and myelination of the peripheral nerve

   Författare :Wilhelm Wallquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Motoneuron; dorsal root ganglion neuron; integrin; laminin; Schwann cell; Sciatic nerve; regeneration; myelination; in situ hybridization; immunohistochemistry and electron microscopy.;

   Sammanfattning : One important prerequisite for successful axon regeneration is that appropriate extracellular molecules are available for outgrowing axons and that receptors for such molecules are found in the regenerating neuron. Laminin associated integrin subunits alpha3, alpha6, alpha7 and beta1 mRNAs are here shown to be present in rat motoneurons, and in the case of integrin subunits alpha7 and gamma1, also immunohistochemical (IHC) labelling of the proteins was demonstrated. LÄS MER

3. 22. Glial cell responses, complement and clusterin expression after lesions in central or peripheral nervous system

   Författare :Li Liu; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Glia; Complement; Clusterin; Proliferation; Peripheral nerve injury; Spinal cord injury; Rhizotomy; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : The present Thesis examines the expression and role of complement and the complement regulator clusterin after central or peripheral axon injury in relation to the responses of non-neuronal cells. Following peripheral sensory nerve injury, complement was expressed in the spinal cord and brain stem in association with reactive microglia, which also appeared to be a local source of complement. LÄS MER

4. 23. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

   Författare :Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

   Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER

5. 24. Mesenchymal stem cells for repair of the peripheral and central nervous system

   Författare :Maria Brohlin; Mikael Wiberg; Martin Birchall; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone marrow-derived stromal cells; Schwann cells; Peripheral nerve injury; Spinal cord injury; Neurotransplantation; anatomi; Human Anatomy; cell research; cellforskning;

   Sammanfattning : Bone marrow-derived mesenchymal stem cells (MSC) have been shown to provide neuroprotection after transplantation into the injured nervous system. The present thesis investigates whether adult human and rat MSC differentiated along a Schwann cell lineage could increase their expression of neurotrophic factors and promote regeneration after transplantation into the injured peripheral nerve and spinal cord. LÄS MER

7. 25. Development of new MRl-based analysis methods for improved diagnosis of low back pain patients

   Författare :Christian Waldenberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; annular fissure; bone marrow lesion; image analysis; intervertebral disc; intervertebral disc degeneration; low back pain; machine learning; radiomics; texture analysis;

   Sammanfattning : BACKGROUND Low back pain (LBP) is the leading cause of disability worldwide, where three of four individuals experience back pain at some point in their lives. The pathophysiological background of LBP is probably multifactorial, where bone marrow damage, tissue changes in the vertebral endplates, and intervertebral disc (IVD) degeneration have been recognized as tissue changes linked to pain. LÄS MER