Sökning: "membrane protein folding"
Visar resultat 1 - 5 av 67 avhandlingar innehållade orden membrane protein folding.
1. Membrane and secretory protein production in Escherichia coli
Sammanfattning : Escherichia coli (E. coli) is the most widely used bacterium for the production of recombinant proteins. However, the production of proteins in its cytoplasmic membrane or periplasm is challenging. Therefore, the aim of this doctoral thesis was to develop setups for enhancing the production of membrane and secretory proteins in E. LÄS MER
2. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding
Sammanfattning : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. LÄS MER
3. Protein and lipid interactions within the respiratory chain : Studies using membrane-mimetic systems
Sammanfattning : Energy conversion from nutrients to ATP is a vital process in cells. The process, called oxidative phosphorylation (OXPHOS) is performed by a combination of membrane-bound proteins. These proteins have been studied in great detail in the past, however much is still unknown about how they interact with each other. LÄS MER
4. Ribosome Associated Factors Recruited for Protein Export and Folding
Sammanfattning : Protein folding and export to the membrane are crucial events in the cell. Both processes may be initiated already at the ribosome, assisted by factors that bind to the polypeptide as it emerges from the ribosome. LÄS MER
5. Membrane chaperones : protein folding in the ER membrane
Sammanfattning : The plasma membrane (PM), comprised largely of lipids and proteins, is a dynamic structure that establishes the integrity of cells. Newly synthesized PM proteins are initially inserted into the endoplasmic reticulum (ER) prior to being targeted to the PM via the secretory pathway. Many PM proteins are polytopic, i.e. LÄS MER