Sökning: "PARP inhibitor"
Visar resultat 1 - 5 av 22 avhandlingar innehållade orden PARP inhibitor.
1. Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products
Sammanfattning : Diphtheria Toxin-like ADP-RibosyltransferasesThe Human ADP-ribosyl transferases (ARTDs) are a group of poorly studied enzymes which are believed to be involved in e.g. DNA repair, protein degradation, transcription regulation and cell death. Medicinal chemistry programmes aimed at developing selective inhibitors of these ARTDs were initiated. LÄS MER
2. Transcriptional Silencing in the Imprinted Igf2-H19 Loci: The Mystique of Epigenetics
Sammanfattning : Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoallelic expression in a non-Mendelian fashion. To restore totipotency and to reset the imprint according to the sex of the individual, the mark must be erased during germline development. LÄS MER
3. Mechanisms of leukemia-induced immunosuppression
Sammanfattning : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. LÄS MER
4. Interplay between Transcription and Homologous Recombination in the Presence of DNA Damage
Sammanfattning : The biochemical processes of DNA repair, replication and recombination compete for the same substrate, the DNA molecule. This competition is natural, as each process requires the same template. In order to resolve possible conflicts between these processes, when they take place on a particular stretch of DNA, certain crosstalk is expected. LÄS MER
5. Cancer stem cells and homologous recombination deficiency in serous ovarian and endometrial carcinoma
Sammanfattning : .... LÄS MER