Sökning: "orientational preference"

Hittade 2 avhandlingar innehållade orden orientational preference.

  1. 1. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding

    Författare :Tuuli Minttu Virkki de Marothy; Arne Elofsson; William Dowhan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein folding; hydrophobicity; translocon; transmembrane helix; marginally hydrophobic transmembrane helices; orientational preference; positive inside rule; aquaporin 1; Biochemistry; biokemi;

    Sammanfattning : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. LÄS MER

  3. 2. A computational approach to curvature sensing in lipid bilayers

    Författare :Federico Elías-Wolff; Alexander Lyubartsev; Max Berkowitz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; curvature sensing; membrane curvature; cardiolipin; amphipathic helix; symmetric multimers; lipid bilayer; molecular dynamics; Biophysics; biofysik;

    Sammanfattning : Local curvature is a key driving force for spatial organization of cellular membranes, via a phenomenon known as membrane curvature sensing, where the binding energy of membrane associated macromolecules depends on the local membrane shape. However, the microscopic mechanisms of curvature sensing are not well understood. LÄS MER