Sökning: "lysosomal enzyme release"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden lysosomal enzyme release.

  1. 1. Cellular mechanisms involved in bone resorption

    Författare :Ulf Lerner; Umeå universitet; []
    Nyckelord :Bone resorption. cyclic AMP; parathyroid hormone; prostaglandins; la OH D3; lysosomal enzyme release; osteoclast; periodontitis; rheumatoid arthritis;

    Sammanfattning : The effects of parathyroid hormone (PTH), prostaglandins (PGE1, PGE2, PGF2a), cAMP, cAMP-analogues, phosphodiesterase (PDE) inhibitors and la (OH) D3 on bone resorption and associated cellular process have been studied in a bone organ culture system using half- calvaria from 6-7 day-old mice. Bone resorption was assessed by determining the release of calcium (Ca2+), inorganic phosphate (Pi) and 45Ca from the calvarial bones to the culture media. LÄS MER

  3. 2. Effects of Total Parenteral Nutrition on the Exocrine and Endocrine Pancreas. An Experimental Study

    Författare :Bo-Guang Fan; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; TPN; Parotid glands; Lysosomal enzyme; Insulin; Hypotrophy; Hyperlipidemia; Food passage; Endocrine pancreas; Cholecystokinin; Exocrine pancreas; traumatology; Kirurgi; ortopedi; traumatologi; Gastro-enterology; Gastroenterologi;

    Sammanfattning : During total parenteral nutrition (TPN) adequate nutrition is provided intravenously and the enteral route is bypassed. The integrity of the gastrointestinal (GI) tract, however, is dependent on the passage of food through it. This thesis deals with the effects of TPN on the pancreas and the parotid glands. LÄS MER

  4. 3. The Lysosomal-Mitochondrial Axis Theory of Apoptosis

    Författare :Ming Zhao; Sten Orrenius; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In many cases, apoptosis may be initiated by a minor lysosomal destabilization, which some time later is followed by a secondary, more pronounced, lysosomal rupture. After exposure to low concentrations of sphingosine, a lysosomotropic detergent, Jurkat and J774 cells underwenr apoptotic cell death, while cells exposed to higher concentrations of this agent showed necrosis. LÄS MER

  5. 4. Cathepsin D released from lysosomes mediates apoptosis

    Författare :Katarina Kågedal; Marja Jäättelä; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Last year (2002), the Nobel Prize in Physiology or Medicine was awarded to three scientists who have conducted pioneer research on programmed cell death. In the human body, more than a thousand billion cells are created every day, and an equal number die, thus programmed cell death, or apoptosis, is an important mechanism for maintaining tissue homeostasis and protecting against disease. LÄS MER

  7. 5. Insulin-like growth factor-II : cellular effects through different receptors

    Författare :Qimin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Insulin-like growth factor-II (IGF-II) and IGF-I are single-chain polypeptides structurally homologous to proinsulin and share similarities with insulin in functional characteristics. Cellular actions of IGF-II are generally thought to be mediated through the IGF-I or insulin receptors, but not the IGF-II receptor, which is a single chain protein, identical to the cation independent mannose 6-phosphate (M6P) receptor and responsible for lysosomal enzyme targeting and degradation of IGF-II. LÄS MER