Sökning: "Qimin Zhang"

Hittade 1 avhandling innehållade orden Qimin Zhang.

1. 1. Insulin-like growth factor-II : cellular effects through different receptors

   Författare :Qimin Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Insulin-like growth factor-II (IGF-II) and IGF-I are single-chain polypeptides structurally homologous to proinsulin and share similarities with insulin in functional characteristics. Cellular actions of IGF-II are generally thought to be mediated through the IGF-I or insulin receptors, but not the IGF-II receptor, which is a single chain protein, identical to the cation independent mannose 6-phosphate (M6P) receptor and responsible for lysosomal enzyme targeting and degradation of IGF-II. LÄS MER