Sökning: "lumefantrine concentrations"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden lumefantrine concentrations.

  1. 1. Development of Analytical Methods for the Determination of Antimalarials in Biological Fluids

    Författare :Daniel Blessborn; Yngve Bergqvist; Anders Helander; Högskolan Dalarna; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Malaria; Chloroquine; Quinine; Sulfadoxine; Pyrimethamine; Mefloquine; Lumefantrine; Amodiaquine; Pyronaridine; Proguanil; Atovaquone; Sampling paper; Dried blood spots; Capillary blood; Antimalarial drugs; Solid-phase extraction; Liquid chromatography.; Chemistry;

    Sammanfattning : The aim of this thesis was to develop analytical methods for measuring antimalarial drugs in biological fluids. Solid phase extraction (SPE) was used for the enrichment and purification of the drugs. LÄS MER

  3. 2. The role of molecular markers in emerging artemether-lumefantrine resistant Plasmodium falciparum

    Författare :Maja Malmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is a devastating disease which kills ~1 million people yearly. The vast majority of lives lost due to malaria are children and pregnant women in sub-Saharan Africa. Although malaria is a treatable disease it continues to be one of the major causes of death, especially in poor settings. LÄS MER

  4. 3. Effect of local food on lumefantrine bioavailability and population pharmacokinetics in Ugandan children with malaria

    Författare :Norah Mwebaza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background. Artemether-lumefantrine (AL) is widely adopted as first-line treatment for uncomplicated malaria. Lumefantrine (LUM), the long acting partner drug is critical for cure by eliminating malaria parasites left after artemether exposure. LÄS MER

  5. 4. Improved malaria case management in under-fives in the era of Artemisinin-based combination therapy in Tanzania

    Författare :Billy Ephraim Ngasala; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malaria microscopy; case management; efficacy; effectiveness; artemether-lumefantrine; retreatment; lumefantrine concentrations; randomized trial; Tanzania;

    Sammanfattning : Early parasite-based diagnosis of malaria prior to treatment is critical for rational drug use, optimal outcome of febrile illness, patient adherence, prevention of parasite drug resistance, and reduced costs of health services. However, most primary health care (PHC) facilities in sub-Saharan Africa have no laboratory support and malaria diagnosis is based on clinical symptoms and signs, which are nonspecific. LÄS MER

  7. 5. Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro

    Författare :Shelton Tendai Mariga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malaria; synergy; combination therapy; Plasmodium falciparum; amodiaquine; lumefantrine; resistance; pharmacodynamics;

    Sammanfattning : Chemotherapy remains the most reliable means for the control of Plasmodium falciparum malaria. Unfortunately the parasite has been able to develop resistance to the majority of the antimalarials currently employed. LÄS MER