Sökning: "lipid droplets"

Visar resultat 21 - 25 av 39 avhandlingar innehållade orden lipid droplets.

  1. 21. Nanobubbles in water - how to identify them and why they are stable

    Författare :Fredrik Eklund; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Digital holographic microscopy; Nanoparticle tracking analysis; Dynamic Light scattering; Nanobubbles;

    Sammanfattning : Gas bubbles smaller than 1 micrometer in water, commonly referred to as nanobubbles, is a growing field of research and innovation. Applications range from medical imaging and drug delivery to mining industry and environmental remediation. LÄS MER

  3. 22. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Författare :Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Sammanfattning : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. LÄS MER

  4. 23. Hormone-Sensitive Lipase, new roles for an old enzyme

    Författare :Ola Hansson; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Vitamin A; Inflammation; Medicine human and vertebrates ; Medicin människa och djur ; Metabolism; Hormone-Sensitive Lipase; Proteomics; Obesity; White adipose tissue; Skeletal muscle;

    Sammanfattning : Hormone-sensitive lipase (HSL) has a wide tissue distribution with the highest expression found in white adipose tissue (WAT). HSL also has a unique ability to hydrolyze a large panel of substrates including acylglycerols, cholesteryl esters and retinyl esters. HSL is potentially a new drug target for the treatment of obesity and type II diabetes. LÄS MER

  5. 24. Thylakoid Membranes and Pancreatic Lipase/Colipase

    Författare :Sinan Cem Emek; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; CCK; Thylakoid Membranes; Colipse; Lipase;

    Sammanfattning : Obesity is a major health problem in the world that increases the occurrence of type-2 diabetes and cardiovascular disease. The reason for obesity is a dysfunction in the regulation of energy balance. It has been shown that dietary fat induces satiety as long as this nutrient stays in the intestine. LÄS MER

  7. 25. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure

    Författare :Andrea Treyer; Per Artursson; Gert Fricker; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular drug bioavailability; unbound drug concentration; drug disposition; ADME; drug transport; drug metabolism membrane partitioning; phospholipid; drug-drug interaction; antisense oligonucleotide; cell-penetrating peptide; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. LÄS MER