Sökning: "Hormone-Sensitive Lipase"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Hormone-Sensitive Lipase.

  1. 1. Monoglyceride Lipase and Hormone-Sensitive Lipase - Molecular and structural aspects

    Författare :Marie Karlsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genomic organisation; baculovirus-insect cells; catalytic triad; alfa beta hydrolase fold; tissue distribution; cDNA sequence; lipolysis; adipocyte; monoglyceride lipase; hormone-sensitive lipase; chromosomal localisation; Clinical biology; Klinisk biologi;

    Sammanfattning : Triglycerides in the adipocyte are hydrolysed by means of three consecutive reactions through the combined action of two lipases: hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). HSL catalyses the first and rate-limiting step, i.e. LÄS MER

  3. 2. Structure-function relationships of hormone-sensitive lipase

    Författare :Torben Österlund; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; mutagenesis; domain; fold; catalytic triad; lipase; structure; enzymology; Proteiner; enzymologi;

    Sammanfattning : The primary role of hormone-sensitive lipase (HSL), an 84 kDa enzyme of 768 amino acids (in the rat protein), is to hydrolyse stored triacylglycerols in adipocytes of white adipose tissue. Catecholamines and insulin regulate lipolysis through cellular signalling. LÄS MER

  4. 3. Hormone-Sensitive Lipase, new roles for an old enzyme

    Författare :Ola Hansson; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Vitamin A; Inflammation; Medicine human and vertebrates ; Medicin människa och djur ; Metabolism; Hormone-Sensitive Lipase; Proteomics; Obesity; White adipose tissue; Skeletal muscle;

    Sammanfattning : Hormone-sensitive lipase (HSL) has a wide tissue distribution with the highest expression found in white adipose tissue (WAT). HSL also has a unique ability to hydrolyze a large panel of substrates including acylglycerols, cholesteryl esters and retinyl esters. HSL is potentially a new drug target for the treatment of obesity and type II diabetes. LÄS MER

  5. 4. Hormone Sensitive Lipase - in vitro phosphorylation

    Författare :Christian Krintel; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Abstract Fatty acids mobilized from triacylglycerol stores are a major energy source in humans. Mobilization occurs through the consecutive action of three lipases: adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). LÄS MER

  7. 5. Hormone-Sensitive Lipase and the Pancreatic Beta-Cell

    Författare :Håkan Lindvall; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetik; cytogenetics; Genetik; Genetics; cloning; gene expression; lipase; insulin secretion; diabetes; lipotoxicity;

    Sammanfattning : Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization. It is acutely regulated by extracellular signals via reversible phosphorylation. In the recent past, the focus of type 2 diabetes research has moved towards the lipid component. LÄS MER