Sökning: "EVs"

Visar resultat 1 - 5 av 111 avhandlingar innehållade ordet EVs.

  1. 1. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Författare :Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Sammanfattning : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. LÄS MER

  3. 2. Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment

    Författare :Helena Christianson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvesicle; exosome; Key words Extracellular vesicle; glioblastoma; hypoxia; angiogenesis; acidosis; proteoglycan; endocytosis; carbonic anhydrase IX; biomarker.;

    Sammanfattning : The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. LÄS MER

  4. 3. Therapeutic potential of extracellular vesicles

    Författare :Oscar Wiklander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Extracellular vesicles (EVs) are nanometer-sized, lipid membrane enclosed, vesicles that are secreted by most, if not all, cells and contain macromolecular material of the source cell including lipids, proteins and various nucleic acid species. Over the last two decades, EVs have been recognized as important mediators of cell-to-cell communication that influence both physiological and pathological conditions. LÄS MER

  5. 4. Aggregation of Plug-in Electric Vehicles in Power Systems for Primary Frequency Control

    Författare :Seyedmahdi Izadkhast; Mehrdad Ghandhari; Garcia-Gonzalez Pablo; Frias Pablo; Ignacio Egido Cortés; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aggregation; Plug-in Electric Vehicles; Primary Frequency Control; Aggregeren; Plug-in Elektrische Voertuigen; Primaire Reserve; Laddbara Bilar; Elnätet; Primär Frekvensreglering; Agregación; Vehículos Eléctricos Enchufables PEVs ; Control Primario de Frecuencia PFC ; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : The number of plug-in electric vehicles (PEVs) is likely to increase in the near future and these vehicles will probably be connected to the electric grid most of the day time. PEVs are interesting options to provide a wide variety of services such as primary frequency control (PFC), because they are able to quickly control their active power using electronic power converters. LÄS MER

  7. 5. Engineered extracellular vesicles for biomedical applications

    Författare :Dhanu Gupta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nature's very own nanoparticle, Extracellular vesicles (EVs), are lipid membrane-enclosed vesicles encapsulated with diverse biomolecules and are actively secreted by all cell types for intercellular communication. The unique properties of EVs, such as stability in circulation, biocompatibility, immune tolerance, and the ability to cross biological barriers, render EVs a next-generation drug delivery tool. LÄS MER