Sökning: "limit of detection"

Visar resultat 11 - 15 av 285 avhandlingar innehållade orden limit of detection.

1. 11. Digital Electrical DNA Sensing

   Författare :Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
   Nyckelord :DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

   Sammanfattning : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. LÄS MER

3. 12. Application of proximity Ligation for Detection of Proteins, Biomolecular Interactions, and Single Copies of Pathogens

   Författare :Sigrun Margret Gustafsdottir; Ulf Landegren; Per-Åke Nygren; Uppsala universitet; []
   Nyckelord :Molecular medicine; Proximity ligation; Cytokines; Microbial pathogens; Protein-DNA interactions; Drug screening; Molekylärmedicin;

   Sammanfattning : Proximity ligation is a recently established technique that can provide answers to questions about the concentration, localization, interactions, modifications and functions of proteins. The method enables sensitive protein measurements with a detection limit in the low femtomolar range in complex biological samples. LÄS MER

4. 13. Analysis of ginesenosides

   Författare :Jian-fang Cui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : New analytical methods were developed in order to evaluate commercial ginseng preparations and to allow studies on urinary excretion of ginsenosides in humans after consumption of ginseng preparations. An optimized alkaline procedure was developed for cleavage of the glycosidic bonds that was clearly superior to previously reported hydrolysis procedures of ginsenosides because of (a) completeness of the reaction and (b) absence of the artifacts found in acid hydrolysis. LÄS MER

5. 14. Pharmacokinetics of the enantiomers of thalidomide

   Författare :Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER

7. 15. Precision mass measurements : Final limit of SMILETRAP I and the developments of SMILETRAP II

   Författare :Andreas Solders; Reinhold Schuch; Juha Äystö; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SMILETRAP; Precision mass spectrometry; Penning trap; Atomic mass; Highly charged ions; Low energy ion storage; Time of flight ion cyclotron resonance; High frequency; Proton mass; QED; g-factor; Physics; Fysik; Physics; fysik;

   Sammanfattning : The subject of this thesis is high-precision mass-measurements performed with Penning trap mass spectrometers (PTMS). In particular it describes the SMILETRAP I PTMS and the final results obtained with it, the masses of 40Ca and that of the proton. LÄS MER