Sökning: "Precision mass spectrometry"

Visar resultat 1 - 5 av 61 avhandlingar innehållade orden Precision mass spectrometry.

  1. 1. Precision mass measurements : Final limit of SMILETRAP I and the developments of SMILETRAP II

    Författare :Andreas Solders; Reinhold Schuch; Juha Äystö; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SMILETRAP; Precision mass spectrometry; Penning trap; Atomic mass; Highly charged ions; Low energy ion storage; Time of flight ion cyclotron resonance; High frequency; Proton mass; QED; g-factor; Physics; Fysik; Physics; fysik;

    Sammanfattning : The subject of this thesis is high-precision mass-measurements performed with Penning trap mass spectrometers (PTMS). In particular it describes the SMILETRAP I PTMS and the final results obtained with it, the masses of 40Ca and that of the proton. LÄS MER

  2. 2. Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry

    Författare :Erik Allard; Jonas Berguist; Per Sjöberg; Risto Kostiainen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; liquid chromatography; mass spectrometry; tandem mass spectrometry; method development; capillary electrophoresis; electrospray ionization; time-of-flight; quantitation; metabolomics; metabonomics; pattern recognition; ximelagatran; melagatran; charge state; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. LÄS MER

  3. 3. SMILETRAP I / II : Precision Improvements in Penning-Trap Mass-Spectrometry

    Författare :Markus Suhonen Linné; Reinhold Schuch; Lutz Schweikhard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Penning trap; Mass spectrometers; Instrumentation and methods for time-of-flight TOF spectroscopy; Highly charged ions; Atomic physics; Atomfysik; fysik; Physics;

    Sammanfattning : This thesis describes the final precision mass measurements with SMILETRAP I, where a relative precision of < 1 ppb (10-9) was reached routinely, and the development of SMILETRAP II, aiming for measurements with < 0.1 ppb relative precision. LÄS MER

  4. 4. Mass Spectrometry with Electrospray Ionization from an Adjustable Gap

    Författare :Patrik Ek; Åsa Emmer; Johan Roeraade; Per M. Claesson; Ulrika Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Electrospray ionization; mass spectrometry; nanoelectrospray; ESI; MS; chip; emitter; gap; liquid bridge; nozzle; peptides; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis the fabrication and analytical evaluation of two new electrospray emitters utilized for mass spectrometry analysis is presented. The emitters are based on a new concept, where the spray orifice can be varied in size. The thesis is based on two papers. All present-day nanoelectrospray emitters have fixed dimensions. LÄS MER

  5. 5. New methods for sensitive analysis with nanoelectrospray ionization mass spectrometry

    Författare :Patrik Ek; Johan Roeraade; Åsa Emmer; Andries P. Bruins; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; electrospray ionization; nanoelectrospray ionization; adjustable gap; emitter; miniaturization; improved sensitivity; nanoliter picoliter sample volumes; Alzheimer’s disease; amyloid-beta Aβ ; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis, new methods that address some current limitations in nanoelectrospray mass spectrometry (nESI-MS) analysis are presented. One of the major objectives is the potential gain in sensitivity that can be obtained when employing the proposed techniques. LÄS MER