Sökning: "hydroxyurea"
Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet hydroxyurea.
1. Validation of Several Nucleoside Tracers as Proliferation Markers
Sammanfattning : Positron emission tomography (PET) is a powerful method for in vivo characterization of tumor biochemistry and clinically has been used for diagnosing and grading of malignancy. A key element in oncology is proliferation potential, a feature that is assumed to be an important indicator of tumor growth. LÄS MER
2. Targeting residual malignant cells in myeloid leukemia
Sammanfattning : Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated with leukemic relapse, mostly with dismal survival outcome. LÄS MER
3. Effects of post-treatments with hydroxyurea and caffeine in G2 on the frequency of chromosomal aberrations induced by physical and chemical agents in mammalian cells
Sammanfattning : .... LÄS MER
4. Structural and functional studies on ribonucleotide reductase protein B2 from Escherichia coli
Sammanfattning : Ribonucleotide reductase catalyzes the reduction of ribonucleotidesto the corresponding deoxyribonucleotides, the building blocks forDNA. The enzyme from Escherichia coli consists of two proteins.Bl and B2. Protein B2 contains two dinuclear iron centers and astable tyrosyl radical. LÄS MER
5. Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression
Sammanfattning : The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by in vitro cytotoxicity assay, and the gene expression pattern in interferon treated patients. LÄS MER