Sökning: "leukemic stem cells"

Visar resultat 6 - 10 av 48 avhandlingar innehållade orden leukemic stem cells.

1. 6. Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells

   Författare :Pernilla Eliasson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Urban Gullberg; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cells; hypoxia; self-renewal; survival; acute myeloid leukemia; FLT3; Cell and molecular biology; Cell- och molekylärbiologi; Haematology; Hematologi;

   Sammanfattning : The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. LÄS MER

3. 7. Development of Adenoviral Vectors for Studying Hematopoietic Stem Cell Function

   Författare :Marcus Järås; Institutionen för laboratoriemedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; hTERT; adenovirus; hematopoietic stem cells; Haematology;

   Sammanfattning : Hematopoietic stem cells (HSCs) are defined by their capacity to self-renew and differentiate into all hematopoietic cell lineages. Postnatally, HSCs reside predominantly in the bone marrow and are relatively rare, but important cells because of their therapeutic potential in bone marrow transplantation protocols and in their involvement in the origin of certain leukemias. LÄS MER

4. 8. Consequences of Shb Deficiency on Hematopoietic Cell Function

   Författare :Karin Gustafsson; Michael Welsh; Martin Bergö; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoiesis; hematopoietic stem cells; myeloid neoplasia; T cells; atopic dermatitis; cell signaling; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. LÄS MER

5. 9. Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies

   Författare :Pingnan Xiao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hematopoietic stem cells (HSCs) reside in bone marrow (BM) microenvironment / niche to self-renew and generate all types of mature blood cells in postnatal life. This process is called hematopoiesis. Normal hematopoiesis is tightly regulated by both intrinsic signaling in HSCs and extrinsic signals from BM niche. LÄS MER

7. 10. Hypoxia inducible factor 1 alpha : dependent and independent regulation of hematopoietic stem cells and leukemia

   Författare :Camilla Halvarsson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Kamil Kranc; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. LÄS MER