Sökning: "leukemic stem cells"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden leukemic stem cells.

  1. 16. In vitro studies of cytostatic drugs and growth factors on leukemic and normal hematopoietic cells : based on in vivo intracellular pharmacokinetics

    Författare :Britt Sundman-Engberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ANLL; Normal bone marrow; in vitro; predictive tests; pharmacokinetics; cytostatic drugs; growthfactors;

    Sammanfattning : The aims were to develop, evaluate and apply in vitro methods for cytostatic drug sensitivity, based on intracellular concentrations found after in vivo infusions. The intracellular pharmacokinetics of anthraquinones and ara-C were compared during and after infusion to leukemic patients. Drug concentrations were evaluated with HPLC. LÄS MER

  3. 17. The methodology and significance of minimal residual disease detection after allogeneic stem cell transplantation

    Författare :Mehmet Uzunel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Minimal Residual Disease; Stem Cell Transplantation; ALL; AML; CML; Relapse;

    Sammanfattning : Allogeneic stem cell transplantation (SCT) is the choice of therapy for leukemia patients who respond poorly to conventional chemotherapy. Despite high remission rates after SCT, relapse of the underlying disease remains one of the most frequent causes of treatment failure. LÄS MER

  4. 18. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Författare :Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. LÄS MER

  5. 19. Methods and biomarkers for outcome prediction after allogeneic hematopoietic stem cell transplantation

    Författare :Darius Sairafi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Allogeneic hematopoietic stem cell transplantation (HSCT) is a potent immunotherapeutic procedure but its usability is limited by a high risk of serious complications. A prerequisite for timely initiation of preventive measures is the availability of predictive methods. LÄS MER

  7. 20. Molecular monitoring of engraftment and leukemia relapse after allogeneic hematopoietic stem cell transplantation

    Författare :Jonas Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Relapse of the underlying disease, graft-versus-host disease (GVHD) and infections are the main complications after allogeneic hematopoietic stem cell transplantation (HSCT). A lower tumor burden increases the likelihood of cure after both chemotherapy and HSCT. LÄS MER