Sökning: "leukemia stem cell"
Visar resultat 1 - 5 av 111 avhandlingar innehållade orden leukemia stem cell.
1. Stem and progenitor cell involvement in acute lymphoblastic leukemia
Sammanfattning : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. LÄS MER
2. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia
Sammanfattning : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. LÄS MER
3. Identification and Characterization of Stem Cells in Preleukemia and Leukemia
Sammanfattning : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. LÄS MER
4. Resolving the Cellular Heterogeneity of Human Hematopoietic Stem and Progenitor Cells. The influence of cellular heterogeneity on ontogeny, ageing and leukemia
Sammanfattning : .... LÄS MER
5. Consequences of Shb Deficiency on Hematopoietic Cell Function
Sammanfattning : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. LÄS MER