Sökning: "intramolecular Diels-Alder reaction"

Hittade 5 avhandlingar innehållade orden intramolecular Diels-Alder reaction.

1. 1. On the Ring-Opening Reaction of Thiophene-1,1-dioxides and the Intramolecular Diels-Alder Reaction of Azanona- and AzadecatrienesI

   Författare :Anders Sebastian Tsirk; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transition states; 3-21G * ; intramolecular Diels-Alder reactions; asymmetric induction; multivariate optimization; kinetic isotope effects; rearrangements; secondary amines; 1-dioxides; Ring-opening reaction; thiophene-1; stereoselectivity.; Organic chemistry; Organisk kemi;

   Sammanfattning : Substituted thiophene-1,1-dioxides were synthesized and their ring-opening reactions with omega-unsaturated secondary amines were investigated; this led to a synthetic route to azatrienes and to the preparation of some polyhydroisoindoles and polyhydroisoquinolines via an intramolecular Diels-Alder reaction. By using 2-substituted pyrrolidines and piperidines various tetrahydrobenzo[f]indolizidines, benzo[b]quinolizidines, tetrahydrobenzo[a]indolizidines and tetrahydro[a]pyrrolizidines could be synthesized via the ring-opening of 3-bromo-2,5-dimmethylthiophene-1,1-dioxide and a subsequent intramolecular Diels-Alder reaction. LÄS MER

3. 2. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

   Författare :Martin H Johansson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

   Sammanfattning : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. LÄS MER

4. 3. Synthesis and Rearrangement of Epoxy Sugars

   Författare :Fritiof Pontén; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; crown ether; silica; Intramoleculaf Diels-Alder reaction; radical allylation; allyl sulfone; sugar epoxide; allyl sulfide; ring-contraction; C-glycoside; a; IMDAF; b-unsaturated aldehyde;

   Sammanfattning : Ring-Contraction of sugar-derived epoxy alcohols, functionalised in position 1 and 6, by treatment with lithium bromide and N, N, N', N'-tetramethylurea in refluxing toluene gave enantiomerically pure a,b-unsaturated aldehydes of furanosides. O-Glycosidic epoxy alcohols gave only one, easily purified, aldehyde in approximately 30-60% yield depending on the substitution pattern. LÄS MER

5. 4. Palladium(0)-Catalyzed Synthesis of Spirocycles and Supercritical Chemistry using a Resistively Heated Flow Reactor

   Författare :Ahmed Adeyemi; Mats Larhed; Luke R. Odell; Kenneth Wärnmark; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Continuous Flow; Resistive heating; Supercritical fluids; high-temperature synthesis; Mizoroki-Heck reaction; Spirooxindoles; Spiroethers; Spirobenzofuranes; Unnatural Amino Acids;

   Sammanfattning : This doctoral thesis focusses on an effective and selective approach to the synthesis of spirocycles using palladium(0)-catalyzed Mizoroki-Heck reactions. In addition, selective and efficient chemistry was highlighted by the design and evaluation of a novel resistively heated system for continuous flow (CF) synthesis for high-temperature and high-pressure applications. LÄS MER

7. 5. Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis

   Författare :Staffan Torssell; Peter Somfai; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; amino alcohol; carbenoid; carbonyl ylide; cross-metathesis; diastereoselective; 1; 3-dipolar cycloaddition; sphingosine; Organisk kemi; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER