Sökning: "intramolecular Diels-Alder reactions"

Hittade 4 avhandlingar innehållade orden intramolecular Diels-Alder reactions.

1. 1. On the Ring-Opening Reaction of Thiophene-1,1-dioxides and the Intramolecular Diels-Alder Reaction of Azanona- and AzadecatrienesI

   Författare :Anders Sebastian Tsirk; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transition states; 3-21G * ; intramolecular Diels-Alder reactions; asymmetric induction; multivariate optimization; kinetic isotope effects; rearrangements; secondary amines; 1-dioxides; Ring-opening reaction; thiophene-1; stereoselectivity.; Organic chemistry; Organisk kemi;

   Sammanfattning : Substituted thiophene-1,1-dioxides were synthesized and their ring-opening reactions with omega-unsaturated secondary amines were investigated; this led to a synthetic route to azatrienes and to the preparation of some polyhydroisoindoles and polyhydroisoquinolines via an intramolecular Diels-Alder reaction. By using 2-substituted pyrrolidines and piperidines various tetrahydrobenzo[f]indolizidines, benzo[b]quinolizidines, tetrahydrobenzo[a]indolizidines and tetrahydro[a]pyrrolizidines could be synthesized via the ring-opening of 3-bromo-2,5-dimmethylthiophene-1,1-dioxide and a subsequent intramolecular Diels-Alder reaction. LÄS MER

3. 2. GALIELLALACTONE ANALOGUES – SYNTHESIS AND PROPERTIES

   Författare :Ritha Gidlöf; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galiellalactone; one-pot peptide coupling and intramolecular Michael addition; tandem palladium-catalyzed carbonylation intramolecular Diels-Alder; STAT3 inhibition;

   Sammanfattning : Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. LÄS MER

4. 3. Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis

   Författare :Staffan Torssell; Peter Somfai; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; amino alcohol; carbenoid; carbonyl ylide; cross-metathesis; diastereoselective; 1; 3-dipolar cycloaddition; sphingosine; Organisk kemi; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER

5. 4. Palladium(0)-Catalyzed Synthesis of Spirocycles and Supercritical Chemistry using a Resistively Heated Flow Reactor

   Författare :Ahmed Adeyemi; Mats Larhed; Luke R. Odell; Kenneth Wärnmark; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Continuous Flow; Resistive heating; Supercritical fluids; high-temperature synthesis; Mizoroki-Heck reaction; Spirooxindoles; Spiroethers; Spirobenzofuranes; Unnatural Amino Acids;

   Sammanfattning : This doctoral thesis focusses on an effective and selective approach to the synthesis of spirocycles using palladium(0)-catalyzed Mizoroki-Heck reactions. In addition, selective and efficient chemistry was highlighted by the design and evaluation of a novel resistively heated system for continuous flow (CF) synthesis for high-temperature and high-pressure applications. LÄS MER