Sökning: "fungal metabolite"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden fungal metabolite.

  1. 1. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Författare :Martin H Johansson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Sammanfattning : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. LÄS MER

  3. 2. Structure and biosynthesis of fungal secondary metabolites : studies of the root rot pathogen Heterobasidion annosum s.l. and the biocontrol fungus Phlebiopsis gigantea

    Författare :David Kälvö; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The root rot pathogen Heterobasidion annosum s.l., i.e. LÄS MER

  4. 3. Analysis of Secondary Metabolites from Aspergillus fumigatus and Penicillium nalgiovense : Antimicrobial Compounds from Filamentous Fungi Isolated from Extreme Environments

    Författare :Stefan Svahn; Lars Bohlin; Björn Olsen; Ulf Göransson; Erja Chryssanthou; Douglas Kinghorn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aspergillus fumigatus; Penicillium nalgiovense; secondary metabolites; invasive aspergillosis; elicitation; gliotoxin; bis methyl gliotoxin; amphotericin B; Pharmacognosy; Farmakognosi;

    Sammanfattning : This thesis describes the cultivation and extraction of filamentous fungi isolated from extreme environments in the search for new antibiotic compounds. Filamentous fungi are a rich source of medicines including antibiotics, and it is believed that many currently unknown fungal species and bioactive fungal metabolites remain to be discovered. LÄS MER

  5. 4. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

    Författare :Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. LÄS MER

  7. 5. Systems Biology of the Secondary Metabolism in Filamentous Fungi

    Författare :Jens Christian Froslev Nielsen; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; genomics; systems biology; secondary metabolites; antibiotics; Next-generation sequencing; secondary metabolism; filamentous fungi; cell factories; Penicillium;

    Sammanfattning : Filamentous fungi constitute a rich reservoir of pharmaceutically relevant bioactive small molecules. These compounds, commonly referred to as secondary metabolites, are widely used as antibiotics for the treatment of microbial infections, but also as other pharmaceuticals such as immunosuppressors, cholesterol lowering agents and anticancer drugs. LÄS MER