Sökning: "imaging mass spectrometry"

Visar resultat 11 - 15 av 91 avhandlingar innehållade orden imaging mass spectrometry.

1. 11. Bioanalysis using capillary electrophoresis and mass spectrometry : Applied on proteins, protein nanofibrils and polyvinyl alcohol microbubbles

   Författare :Leila Josefsson; Åsa Emmer; Ulrika Nilsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; : amyloid; capillary electrophoresis; contrast agents; detection; human blood plasma; ionic liquids; mass spectrometry; microbubbles; polyvinyl alcohol microbubbles; protein nanofibrils; proteins; Kemi; Chemistry;

   Sammanfattning : The sequencing of the genome of various species, including the human species, have led to increased understanding about how a protein structure is generated, and how specific structures are related to the proteins’ functionality. In paper I and II of this thesis, the folding of proteins in vitro to form hierarchical nanostructures, which in vivo often have a pathological effect, have been studied. LÄS MER

3. 12. Molecular Signatures of Neuropathic Pain : Revealing Pain-Related Signaling Processes in Spinal Cord Using Mass Spectrometric Methodologies

   Författare :Ping Sui; Jonas Bergquist; Konstantin Artemenko; Janne Lehtiö; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mass spectrometry; Spinal cord; Neuropathic pain; Quantitative proteomics; Imaging mass spectrometry; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. LÄS MER

4. 13. Spatial analysis of lipids in tissue samples applying mass spectrometry imaging

   Författare :Masoumeh Dowlatshahi Pour; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SIMS; MALDI; Mass spectrometry imaging; Lipid; ME-SIMS; Sample preparation;

   Sammanfattning : Lipids are important naturally occurring components in all living cellular organisms. They serve as the main building blocks of cellular membranes, participate in many signaling pathways and are also stored as an energy source. LÄS MER

5. 14. Molecular and epidemiological studies on eyes with pseudoexfoliation syndrome

   Författare :Amelie Botling Taube; Jonas Bergquist; Albert Alm; Eva Larsson; Hannu Uusitalo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseduoexfoliation syndrome; PEX; aqueous humor; cataract; cataract surgery; lens capsule; proteomics; mass spectrometry; MS; MALDI TOF MS MS; quantitative proteomics; iTRAQ; dimethyl labeling; imaging mass spectrometry; IMS; time of flight secondary ion mass spectrometry; TOF-SIMS; crystallin; epidemiology; risk factor; Ophtalmology; Oftalmiatrik;

   Sammanfattning : Pseudoexfoliation (PEX) syndrome is an age-related condition characterized by the production and accumulation of extracellular fibrillary material in the anterior segment of the eye. PEX predisposes for several pathological conditions, such as glaucoma and complications during and after cataract surgery. LÄS MER

7. 15. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry

   Författare :Louise M Carlred; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; GM1; cholesterol; Amyloid-β; phospholipids; Imaging Mass Spectrometry; Alzheimer’s disease; sulfatides; QCM-D; MALDI;

   Sammanfattning : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. LÄS MER