Sökning: "GM1"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet GM1.

  1. 1. Evaluation of fucosylated receptors for Cholera toxin in the human small intestine

    Författare :Jakob Cervin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; Lewis antigen; HBGA; HMO; Fucose; GM1;

    Sammanfattning : Cholera toxin (CT) produced by Vibrio cholerae is the causative agent for the diarrheal disease cholera. Cholera is yearly afflicting millions and is estimated to kill over 100 000 people every year. In this thesis I aimed to better understand the role of noncanonical CT receptors, e.g. LÄS MER

  3. 2. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry

    Författare :Louise M Carlred; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; GM1; cholesterol; Amyloid-β; phospholipids; Imaging Mass Spectrometry; Alzheimer’s disease; sulfatides; QCM-D; MALDI;

    Sammanfattning : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. LÄS MER

  4. 3. Fluorescence studies of complex systems : organisation of biomolecules

    Författare :Denys Marushchak; Lennart B.A. Johansson; Alexander Lyubartsev; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fluorescence anisotropy; BODIPY; homo and hetero dimerisation; protein aggregates; protein polymer structures; actin polymerisation; FRET; donor–acceptor energy transfer DAET; donor-donor energy migration DDEM; homotransfer; Monte Carlo simulation; MC; Brownian dynamics; BD; Genetic Algorithm; GA.; Ganglioside GM1; Biophysical chemistry; Biofysikalisk kemi;

    Sammanfattning : The homo and hetero dimerisation of two spectroscopically different chromophores were studied, namely: 4,4-difluoro-4-bora-3a,4a-diazas-indacene (g-BODIPY) and its 5-styryl-derivative (r-BODIPY). Various spectroscopic properties of the r-BODIPY in different common solvents were determined. LÄS MER

  5. 4. Optical characterization of potential drugs and drug delivery systems

    Författare :Erik Rosenbaum; Lennart B-Å Johansson; Sven Engström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pilicide; Ganglioside GM1 micelles; Drug Delivery; Elecronic Energy Transfer; UV-Vis Absorption; Fluorescence Spectroscopy; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

    Sammanfattning : This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. LÄS MER

  7. 5. Studies on pneumococcal polysaccharides and their effect on immune cells

    Författare :Marianne Sundberg Kövamees; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae is a major cause of morbidity and mortality in children and adults worldwide. The spectrum of infections caused by Streptococcus pneumoniae is well-characterized. LÄS MER